Volume 366, Issue 9494, Pages (October 2005)

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Volume 366, Issue 9494, Pages 1359-1366 (October 2005) RETRACTED: Non-steroidal anti-inflammatory drugs and the risk of oral cancer: a nested case-control study Dr J Sudbø, MD, Prof JJ Lee, PhD, Prof SM Lippman, MD, J Mork, MD, S Sagen, MPH, N Flatner, DDS, A Ristimäki, MD, Prof A Sudbø, PhD, Prof L Mao, MD, X Zhou, MSc, W Kildal, MSc, JF Evensen, MD, Prof A Reith, MD, Prof AJ Dannenberg, MD The Lancet Volume 366, Issue 9494, Pages 1359-1366 (October 2005) DOI: 10.1016/S0140-6736(05)67488-0 Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 1 Identification process of study cohorts The Lancet 2005 366, 1359-1366DOI: (10.1016/S0140-6736(05)67488-0) Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 2 Cancer-free and overall survival related to NSAID use (A) Cancer-free survival. (B) Relation between cancer-free survival and duration of NSAID use. (C) Cancer-free survival after smoking cessation in people with no history of NSAID or paracetamol use. (D) Overall mortality. Kaplan-Meier curves go to zero because the risk set reduces over time, mainly because of censoring and late events (ie, oral cancer developing at older ages). E/N=number of events/total number of individuals in subgroup. Tick marks on Kaplan-Meier curves=censored data. The Lancet 2005 366, 1359-1366DOI: (10.1016/S0140-6736(05)67488-0) Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 3 Cancer protective effect of NSAID use as related to smoking habits Blue=people with no history of NSAID use. Red=people with history of NSAID use. (A) Oral-cancer-free survival in 341 active smokers with smoking history of less than 40 pack-years. (B) Oral-cancer-free survival in 351 active smokers with smoking history of 40 or more pack-years. (C) Oral-cancer-free survival in 134 people who had quit smoking with a smoking history of less than 40 pack-years. (D) Oral-cancer-free survival in 82 people who had quit smoking with a smoking history of 40 or more pack-years. E/N=number of events/total number of individuals in subgroup. Tick marks on Kaplan-Meier curves=censored data. The Lancet 2005 366, 1359-1366DOI: (10.1016/S0140-6736(05)67488-0) Copyright © 2005 Elsevier Ltd Terms and Conditions