Volume 120, Issue 7, Pages 1630-1639 (June 2001) Extent of high-grade dysplasia in Barrett's esophagus correlates with risk of adenocarcinoma Navtej S. Buttar, Kenneth K. Wang, Thomas J. Sebo, Darren M. Riehle, Krishnawatie K. Krishnadath, Lori S. Lutzke, Marlys A. Anderson, Tanya M. Petterson, Lawrence J. Burgart Gastroenterology Volume 120, Issue 7, Pages 1630-1639 (June 2001) DOI: 10.1053/gast.2001.25111 Copyright © 2001 American Gastroenterological Association Terms and Conditions
Fig. 1 Photomicrographs representing focal HGD. Arrows showing 2 crypts involved by HGD. The extent of HGD was defined as focal if cytologic and/or architectural changes of HGD were limited to a single focus of 5 or fewer crypts in 1 biopsy specimen of an entire set of surveillance biopsy specimens. Original magnification: 10X (A); 40X (B). Gastroenterology 2001 120, 1630-1639DOI: (10.1053/gast.2001.25111) Copyright © 2001 American Gastroenterological Association Terms and Conditions
Fig. 2 Flow diagram outlining the patient exclusion criteria. Gastroenterology 2001 120, 1630-1639DOI: (10.1053/gast.2001.25111) Copyright © 2001 American Gastroenterological Association Terms and Conditions
Fig. 3 The Kaplan–Meier curves comparing focal and diffuse HGD are shown. The percentage of patients that are cancer free at a given time period is shown on the y-axis, whereas the duration of follow-up from the index date in years is shown on the x-axis. Vertical bars indicate the 95% CI. Using the log-rank statistic, the P value is 0.0006. Gastroenterology 2001 120, 1630-1639DOI: (10.1053/gast.2001.25111) Copyright © 2001 American Gastroenterological Association Terms and Conditions