Nitric oxide and glomerulonephritis

Slides:

Advertisements

Similar presentations

Volume 58, Issue 5, Pages (November 2000)

Advertisements

Volume 64, Issue 6, Pages (December 2003)

Volume 81, Issue 2, Pages (January 2012)

Volume 56, Issue 4, Pages (October 1999)

Volume 66, Issue 3, Pages (September 2004)

Volume 61, Issue 2, Pages (February 2002)

Volume 61, Issue 4, Pages (April 2002)

Volume 55, Issue 2, Pages (February 1999)

Ganesan Ramesh, W. Brian Reeves Kidney International

Volume 62, Issue 2, Pages (August 2002)

Volume 67, Issue 5, Pages (May 2005)

Volume 63, Issue 4, Pages (April 2003)

Volume 66, Issue 6, Pages (December 2004)

Volume 75, Issue 10, Pages (May 2009)

Volume 62, Issue 6, Pages (December 2002)

Mukut Sharma, Ellen T. Mccarthy, Virginia J. Savin, Elias A. Lianos

Wolfgang Eberhardt, Karl-Friedrich Beck, Josef Pfeilschifter

Volume 59, Issue 3, Pages (March 2001)

Volume 57, Issue 3, Pages (March 2000)

Volume 56, Issue 6, Pages (December 1999)

Volume 64, Issue 5, Pages (November 2003)

Vitamin E treatment of experimental glomerular disease in rats

Volume 57, Issue 3, Pages (March 2000)

Volume 59, Issue 1, Pages (January 2001)

Volume 77, Issue 5, Pages (March 2010)

Volume 68, Issue 1, Pages (July 2005)

Volume 64, Issue 2, Pages (August 2003)

Volume 55, Issue 4, Pages (April 1999)

Volume 56, Issue 3, Pages (September 1999)

Volume 79, Issue 8, Pages (April 2011)

Volume 62, Issue 5, Pages (November 2002)

Volume 68, Issue 2, Pages (August 2005)

Volume 60, Issue 6, Pages (December 2001)

Volume 53, Issue 5, Pages (May 1998)

Volume 58, Issue 1, Pages (July 2000)

Volume 73, Issue 1, Pages (January 2008)

Arginase in glomerulonephritis

Volume 70, Issue 2, Pages (July 2006)

Volume 67, Issue 1, Pages (January 2005)

Julia E. Tank, Orson W. Moe, William L. Henrich Kidney International

Local delivery of angiotensin receptor blocker into the kidney ameliorates progression of experimental glomerulonephritis J. Mahmood, F. Khan, S. Okada,

Volume 53, Issue 5, Pages (May 1998)

Blockade of NFκB activation and renal inflammation by ultrasound-mediated gene transfer of Smad7 in rat remnant kidney Yee-Yung Ng, Chun-Cheng Hou, Wansheng.

Volume 61, Issue 6, Pages (June 2002)

Volume 71, Issue 7, Pages (April 2007)

Effect of nitric oxide modulation on TGF-β1 and matrix proteins in chronic cyclosporine nephrotoxicity Fuad S. Shihab, Hong Yi, William M. Bennett, Takeshi.

Volume 62, Issue 5, Pages (November 2002)

Volume 81, Issue 2, Pages (January 2012)

Nitric oxide in acute renal failure: NOS versus NOS

Volume 61, Issue 6, Pages (June 2002)

Nephrology Crossword: Glomerulonephritis

Volume 65, Issue 6, Pages (June 2004)

Volume 80, Issue 3, Pages (August 2011)

H+-ATPase activity on unilateral ureteral obstruction: Interaction of endogenous nitric oxide and angiotensin II Patricia G. Valles, Walter A. Manucha

Volume 68, Issue 6, Pages (December 2005)

Prasun K. Datta, Elias A. Lianos Kidney International

Volume 82, Issue 9, Pages (November 2012)

TGF-β type II receptor deficiency prevents renal injury via decrease in ERK activity in crescentic glomerulonephritis C.Y. Song, B.C. Kim, H.K. Hong,

Volume 72, Issue 3, Pages (August 2007)

Volume 58, Issue 5, Pages (November 2000)

Jens Gaedeke, Nancy A. Noble, Wayne A. Border Kidney International

Volume 62, Issue 5, (November 2002)

Volume 75, Issue 6, Pages (March 2009)

IL-1β induces VEGF, independently of PGE2 induction, mainly through the PI3-K/mTOR pathway in renal mesangial cells D. Solà-Villà, M. Camacho, R. Solà,

Volume 61, Issue 2, Pages (February 2002)

T-PA promotes glomerular plasmin generation and matrix degradation in experimental glomerulonephritis Masashi Haraguchi, Wayne A. Border, Yufeng Huang,

Volume 61, Issue 3, Pages (March 2002)

Volume 57, Issue 1, Pages (January 2000)

Volume 55, Issue 4, Pages (April 1999)

Volume 56, Issue 4, Pages (October 1999)

Presentation transcript:

Nitric oxide and glomerulonephritis Victoria Cattell Kidney International Volume 61, Issue 3, Pages 816-821 (March 2002) DOI: 10.1046/j.1523-1755.2002.00226.x Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 1 Generation of nitrite (NO2-) by isolated glomeruli (gl) at intervals from 1 to 21 days after induction of accelerated nephrotoxic nephritis (ANTN). (A) Glomerular NO2- nm/2000 gl/48 h. The solid columns (▪) denote the macrophage (mø) numbers/gl. (B) Linear glomerular NO2- over a 48-hour incubation period. (C) Inhibition of glomerular NO2- by increasing concentrations of L-NMMA (0 to 50 μmol/L), reversed by 0.4mmol/L L-arginine. Kidney International 2002 61, 816-821DOI: (10.1046/j.1523-1755.2002.00226.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 2 Initial 24 hours after induction of heterologous nephrotoxic nephritis (HNTN). (A) Time course of leukocyte infiltration. Abbreviations are: mø, macrophages (dashed line); pmn, neutrophils (solid line). (B) Glomerular NO2- generation and iNOS mRNA induction. Kidney International 2002 61, 816-821DOI: (10.1046/j.1523-1755.2002.00226.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 3 Pattern of glomerular NO2- generation and histological changes in anti-Thy 1 GN. (a) Mesangiolysis, (b) aneurysm formation, (c) mesangial proliferation are shown. Kidney International 2002 61, 816-821DOI: (10.1046/j.1523-1755.2002.00226.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 4 Effects of N acetyl cysteine (NAC) in anti-Thy 1 GN. (A) Glomerular iNOS mRNA induction at two hours, RT-PCR doubling dilutions of template from 4 representative rats, 2 control and 2 NAC treated (B) glomerular NO2- generation [(▪) NAC-treated, (□) controls], (C) glomerular chemiluminescence (RLU = relative light units/600 gl) over one hour incubation period [(♦) NAC-treated, (•) controls]. Kidney International 2002 61, 816-821DOI: (10.1046/j.1523-1755.2002.00226.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 5 Summary of induction of nitric oxide (NO) synthesis and its potential roles in glomerulonephritis. Kidney International 2002 61, 816-821DOI: (10.1046/j.1523-1755.2002.00226.x) Copyright © 2002 International Society of Nephrology Terms and Conditions