A DPYD Variant (Y186C) Specific to Individuals of African Descent in a Patient With Life-Threatening 5-FU Toxic Effects: Potential for an Individualized.

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A DPYD Variant (Y186C) Specific to Individuals of African Descent in a Patient With Life-Threatening 5-FU Toxic Effects: Potential for an Individualized Medicine Approach Muhammad Wasif Saif, MD, Adam M. Lee, PhD, Steven M. Offer, PhD, Kathleen McConnell, RN, Valerie Relias, PharmD, Robert B. Diasio, MD Mayo Clinic Proceedings Volume 89, Issue 1, Pages 131-136 (January 2014) DOI: 10.1016/j.mayocp.2013.09.008 Copyright © 2014 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure Absolute neutrophil count (ANC) of an African American patient who experienced 5-fluorouracil toxic effects after the administration of FOLFOX (5-fluorouracil, leucovorin, oxaliplatin). Day 0 indicates the day of chemotherapy administration. The ANC quickly declined to 0 by day 11 after the administration of FOLFOX and remained at approximately 0 until 20 days after chemotherapy. Mayo Clinic Proceedings 2014 89, 131-136DOI: (10.1016/j.mayocp.2013.09.008) Copyright © 2014 Mayo Foundation for Medical Education and Research Terms and Conditions