Antimüllerian hormone and antral follicle count are lower in female cancer survivors and healthy women taking hormonal contraception Lauren N.C. Johnson,

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Presentation transcript:

Antimüllerian hormone and antral follicle count are lower in female cancer survivors and healthy women taking hormonal contraception Lauren N.C. Johnson, M.D., Mary D. Sammel, Sc.D., Katherine E. Dillon, M.D., Lara Lechtenberg, B.A., Allison Schanne, B.A., Clarisa R. Gracia, M.D., M.S.C.E. Fertility and Sterility Volume 102, Issue 3, Pages 774-781.e3 (September 2014) DOI: 10.1016/j.fertnstert.2014.05.026 Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 1 (A) Antimüllerian hormone (AMH) levels and (B) antral follicle counts for visits in hormonal contraception (HC) users vs. nonusers stratified by cancer history. Data are presented as unadjusted geometric means and 95% confidence intervals. Graphs include data from 61 visits among survivors recently exposed to HC, 191 visits among survivors not recently exposed to HC, 11 visits among healthy control subjects recently exposed to HC, and 229 visits among healthy control subjects not recently exposed to HC. Fertility and Sterility 2014 102, 774-781.e3DOI: (10.1016/j.fertnstert.2014.05.026) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Antimüllerian hormone (AMH) levels and antral follicle counts (AFCs) among individuals over time. Plots of AMH levels and AFCs over time for individual subjects illustrate the decline in ovarian reserve markers observed in the setting of recent hormonal contraception (HC) use. Data points labeled “HC” indicate that the subject had taken hormonal contraception within 3 months of the study visit, and “no HC” indicates no exposure to hormonal contraception in the preceding 3 months. (A) AMH and (B) AFC for an 18-year-old woman who was diagnosed with Wilms tumor at age 8. (C) AMH and (D) AFC for a 24-year-old woman who was diagnosed with acute lymphocytic leukemia at age 2. (E) AMH and (F) AFC for a 29-year-old woman who was diagnosed with Hodgkin lymphoma at age 20. (G) AMH and (H) AFC for a 30-year-old healthy woman who enrolled as a control subject. Fertility and Sterility 2014 102, 774-781.e3DOI: (10.1016/j.fertnstert.2014.05.026) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions