PC220 Angiotensin 1-7 Suppresses Experimental Abdominal Aortic Aneurysms Gang Li, Baohui Xu, Hongping Deng, Anna Cabot, Hai Yuan, Xuejun Wu, Sara A. Michie,

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PC220 Angiotensin 1-7 Suppresses Experimental Abdominal Aortic Aneurysms Gang Li, Baohui Xu, Hongping Deng, Anna Cabot, Hai Yuan, Xuejun Wu, Sara A. Michie, Ronald L. Dalman Journal of Vascular Surgery Volume 65, Issue 6, Pages 198S-199S (June 2017) DOI: 10.1016/j.jvs.2017.03.375 Copyright © 2017 Terms and Conditions

Fig Angiotensin (Ang) 1-7 suppresses experimental abdominal aortic aneurysms (AAAs). Male C57BL/6J mice at age 10 to 12 weeks underwent intra-aortic porcine pancreatic elastase (PPE) infusion and received a subcutaneous injection of Ang 1-7 alone or with A779 (0.5 mg/kg/day) beginning (A-H) immediately before PPE infusion and for 14 days thereafter or beginning (I) 4 days thereafter for 10 days. A, Aortic diameter measured via ultrasound imaging. Quantification of (B) medial elastin degradation and (C) smooth muscle cell (SMC) depletion, (D) CD68+ macrophages, (E) CD4+ T cells, (F) CD8+ T cells, (G) B220+, and (H) CD31+ neovessels. I, Influence on further aneurysm enlargement in mice with existing AAAs. All data are mean and standard deviation (n = 7-9 mice per group). ACS, Aortic cross-section. Two-way analysis of variance, followed by two-sample test, *P <.05 compared with vehicle treatment (A and I). Mann-Whitney test, .05 < #P <.1, *P <.05 and **P <.01 compared with vehicle treatment (B-H). Journal of Vascular Surgery 2017 65, 198S-199SDOI: (10.1016/j.jvs.2017.03.375) Copyright © 2017 Terms and Conditions