Boulos Toursarkissian, MD, David Schwartz, MD, PhD, Paul R

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Presentation transcript:

Arterial thrombosis induces early upregulation of intercellular adhesion molecule in the media Boulos Toursarkissian, MD, David Schwartz, MD, PhD, Paul R. Eisenberg, MD, MPH, Brian G. Rubin, MD Journal of Vascular Surgery Volume 26, Issue 4, Pages 663-669 (October 1997) DOI: 10.1016/S0741-5214(97)70067-3 Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Verhoeff–van Gieson stain of thrombosed vessel at 1 week (original magnification, 100×) shows intact internal elastic lamina. Journal of Vascular Surgery 1997 26, 663-669DOI: (10.1016/S0741-5214(97)70067-3) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Immunohistochemical staining for ICAM. A, B, and C show control (C-dis) vessels at 6 hours, 1 day, and 1 week, respectively, without evidence of ICAM staining in media. D, E, and F show thrombosed (Thr-lig) vessels at 6 hours, 1 day, and 1 week, respectively, with increasing medial ICAM expression. Original magnification, 100×. Journal of Vascular Surgery 1997 26, 663-669DOI: (10.1016/S0741-5214(97)70067-3) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Immunohistochemical staining for ICAM. A, B, and C show control (C-dis) vessels at 6 hours, 1 day, and 1 week, respectively, without evidence of ICAM staining in media. D, E, and F show thrombosed (Thr-lig) vessels at 6 hours, 1 day, and 1 week, respectively, with increasing medial ICAM expression. Original magnification, 100×. Journal of Vascular Surgery 1997 26, 663-669DOI: (10.1016/S0741-5214(97)70067-3) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Immunohistochemical staining for ICAM. A, B, and C show control (C-dis) vessels at 6 hours, 1 day, and 1 week, respectively, without evidence of ICAM staining in media. D, E, and F show thrombosed (Thr-lig) vessels at 6 hours, 1 day, and 1 week, respectively, with increasing medial ICAM expression. Original magnification, 100×. Journal of Vascular Surgery 1997 26, 663-669DOI: (10.1016/S0741-5214(97)70067-3) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Immunohistochemical staining for ICAM. A, B, and C show control (C-dis) vessels at 6 hours, 1 day, and 1 week, respectively, without evidence of ICAM staining in media. D, E, and F show thrombosed (Thr-lig) vessels at 6 hours, 1 day, and 1 week, respectively, with increasing medial ICAM expression. Original magnification, 100×. Journal of Vascular Surgery 1997 26, 663-669DOI: (10.1016/S0741-5214(97)70067-3) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Immunohistochemical staining for ICAM. A, B, and C show control (C-dis) vessels at 6 hours, 1 day, and 1 week, respectively, without evidence of ICAM staining in media. D, E, and F show thrombosed (Thr-lig) vessels at 6 hours, 1 day, and 1 week, respectively, with increasing medial ICAM expression. Original magnification, 100×. Journal of Vascular Surgery 1997 26, 663-669DOI: (10.1016/S0741-5214(97)70067-3) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Immunohistochemical staining for ICAM. A, B, and C show control (C-dis) vessels at 6 hours, 1 day, and 1 week, respectively, without evidence of ICAM staining in media. D, E, and F show thrombosed (Thr-lig) vessels at 6 hours, 1 day, and 1 week, respectively, with increasing medial ICAM expression. Original magnification, 100×. Journal of Vascular Surgery 1997 26, 663-669DOI: (10.1016/S0741-5214(97)70067-3) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Immunohistochemical stains of serial sections of a vessel after 1 week of thrombosis. A, Stained for ICAM; B, stained for α-actin. Regions of vessel wall that stained positive for α-actin also stained positive for ICAM. Original magnification, 100×. Journal of Vascular Surgery 1997 26, 663-669DOI: (10.1016/S0741-5214(97)70067-3) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Immunohistochemical stains of serial sections of a vessel after 1 week of thrombosis. A, Stained for ICAM; B, stained for α-actin. Regions of vessel wall that stained positive for α-actin also stained positive for ICAM. Original magnification, 100×. Journal of Vascular Surgery 1997 26, 663-669DOI: (10.1016/S0741-5214(97)70067-3) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions