Deficiency in myeloid-resident NRP1 affects systemic metabolism.

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Deficiency in myeloid-resident NRP1 affects systemic metabolism. Deficiency in myeloid-resident NRP1 affects systemic metabolism. Daily food intake (A) and total beam breaks (B) of control and LysM-Cre-Nrp1fl/fl mice after 18 weeks on a regular diet. Daily food intake (C) and total beam breaks (D) of control and LysM-Cre-Nrp1fl/fl of 18-week-old mice after 10 weeks on HFD. VO2 (E), heat production (F), and RER (G) of control and LysM-Cre-Nrp1fl/fl mice 18 weeks on a regular diet. VO2 (H), heat production (I), and RER (J) of control and LysM-Cre-Nrp1fl/fl of 18-week-old mice after 10 weeks on HFD. Data are means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, Student’s unpaired t test (A and C) and two-way ANOVA with Bonferroni post hoc test (B and D to J) (n = 24, four mice per group). All graph points represent an average calculated over 7 days of measurements. Ariel Molly Wilson et al. Sci. Immunol. 2018;3:eaan4626 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works