Differential sensitivity of thoracic malignant tumors to adenovirus-mediated drug sensitization gene therapy W.Roy Smythe, MDa (by invitation), Harry.

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Presentation transcript:

Differential sensitivity of thoracic malignant tumors to adenovirus-mediated drug sensitization gene therapy W.Roy Smythe, MDa (by invitation), Harry C. Hwang, MDb (by invitation), Ashraf A. Elshami, MDb (by invitation), Kunjlata M. Amin, PhDa (by invitation), Steven M. Albelda, MDb (by invitation), Larry R. Kaiser, MDa The Journal of Thoracic and Cardiovascular Surgery Volume 109, Issue 4, Pages 626-631 (April 1995) DOI: 10.1016/S0022-5223(95)70342-X Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 1 Recombinant replication-deficient adenovirus gene transfer. The basic sequence of steps involved in adenovirus gene transfer leading to novel protein production in human tumor cells is schematically diagrammed. DNA, Deoxyribonucleic acid. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 626-631DOI: (10.1016/S0022-5223(95)70342-X) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 2 Comparison of human cell line sensitivity to adenovirus vector-mediated HSVtk system and αv integrin expression. No obvious relationship exists. Cell line 1, 1-45; line 2, Calu-6; line 3, SK-MES-1; line 4, REN; line 5, H460; line 6, HPM; line 7, A549; line 8, H1264. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 626-631DOI: (10.1016/S0022-5223(95)70342-X) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 3 Comparison of human cell line sensitivity to adenovirus vector-mediated HSVtk system and Ad.CMVlacZ transduction efficiency. The magnitude of simple lines fit to these curves is similar. (See cell line legend to Fig. 2.) The Journal of Thoracic and Cardiovascular Surgery 1995 109, 626-631DOI: (10.1016/S0022-5223(95)70342-X) Copyright © 1995 Mosby, Inc. Terms and Conditions