A Novel Large-Animal Model of Peripheral Arterial Disease

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Presentation transcript:

A Novel Large-Animal Model of Peripheral Arterial Disease Chandler A. Long, Michael Sweet, Tatiana Chadid, Panagiotis Koutakis, Traci Goodchild, David Lefer, Iraklis Pipinos, George Casale, W. Robert Taylor, Luke Brewster Journal of Vascular Surgery Volume 63, Issue 1, Pages 293-294 (January 2016) DOI: 10.1016/j.jvs.2015.10.045 Copyright © 2016 Terms and Conditions

Fig 1 Arteriogenesis in the Yorkshire but not the Ossabaw swine. A, Preocclusion aortogram with equal sized IIA (blue double arrows). B, Arteriogenesis of right compared with left internal iliac artery (blue double arrows). C, Robust angiogenesis in Yorkshire aortogram but not in the (D) Ossabaw swine, which have metabolic syndrome. NS, Not significant; ∗P < .01. Journal of Vascular Surgery 2016 63, 293-294DOI: (10.1016/j.jvs.2015.10.045) Copyright © 2016 Terms and Conditions

Fig 2 Graphic representation of hind limb index (HLI) and duplex velocity over time. Sustained ischemia in Yorkshire (A) HLI and (B) duplex velocities, but there is recovery over time that correlated with increasing systolic velocity. ∗P < .05. Journal of Vascular Surgery 2016 63, 293-294DOI: (10.1016/j.jvs.2015.10.045) Copyright © 2016 Terms and Conditions