Osteoarthritis year in review 2015: biology

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Osteoarthritis year in review 2015: biology A.M. Malfait Osteoarthritis and Cartilage Volume 24, Issue 1, Pages 21-26 (January 2016) DOI: 10.1016/j.joca.2015.09.010 Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Research in the past year has focused on a multitude of pro-inflammatory and pro-catabolic pathways that initiate and maintain dramatic changes in chondrocyte phenotype, cartilage homeostasis, and in the synovium. The integration of the different pathways results in complex networks that drive disease progression, affect other articular tissues such as the subchondral bone, and promote pain. These networks may be modulated by factors such as obesity, diet, age, and joint injury. Osteoarthritis and Cartilage 2016 24, 21-26DOI: (10.1016/j.joca.2015.09.010) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions