mpJX-594 effects on tumor burden and leukocyte influx.

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mpJX-594 effects on tumor burden and leukocyte influx. mpJX-594 effects on tumor burden and leukocyte influx. A, Tumor size indicated by staining of tumor cells for insulin (red) and pancreatic acinar cells for amylase (green) at 5 days after one dose of vehicle (left) or mpJX-594 (right). Graph shows corresponding measurements of tumor burden estimated as combined area of all tumors in sections of pancreas (see Materials and Methods). Student t test: *, P < 0.05 compared with vehicle (n = 5 mice/group). B, Confocal micrographs of leukocytes (CD45, green) and blood vessels (CD31, red) in RIP-Tag2 tumors at 5 days after vehicle or mpJX-594. C, Confocal micrographs show greater abundance of CD8+ T cells (green) in tumors after mpJX-594. Blood vessels, CD31, red. D, Flow cytometry plots of CD45+/CD3+ cells (from all living cells in tumor) and CD4+/CD8+ cells (from CD45+/CD3+ fraction) isolated from tumors show increases in CD3+ cells and CD8+ cells (percentages in corners) at 5 days after mpJX-594. Scale bar, 3 mm in A and 100 μm in C. Minah Kim et al. Cancer Res 2018;78:922-937 ©2018 by American Association for Cancer Research