Continuous Subcutaneous Administration of High-Dose Salmon Calcitonin in Bone Metastasis Kyriaki Mystakidou, MD, PhD, Sofia Befon, MD, Kostas Hondros,

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Continuous Subcutaneous Administration of High-Dose Salmon Calcitonin in Bone Metastasis Kyriaki Mystakidou, MD, PhD, Sofia Befon, MD, Kostas Hondros, PhD, Evagelia Kouskouni, MD, PhD, Labros Vlahos, MD, PhD Journal of Pain and Symptom Management Volume 18, Issue 5, Pages 323-330 (November 1999) DOI: 10.1016/S0885-3924(99)00081-0

Fig. 1 Pain score reduction during the study time period Journal of Pain and Symptom Management 1999 18, 323-330DOI: (10.1016/S0885-3924(99)00081-0)

Fig. 2 Beta-endorphin plasma level variation vs. time Journal of Pain and Symptom Management 1999 18, 323-330DOI: (10.1016/S0885-3924(99)00081-0)

Fig. 3 Twelve-hour change of beta-endorphin plasma levels—pain score Journal of Pain and Symptom Management 1999 18, 323-330DOI: (10.1016/S0885-3924(99)00081-0)

Fig. 4 Twenty-four hour change of beta-endorphin plasma levels—pain score Journal of Pain and Symptom Management 1999 18, 323-330DOI: (10.1016/S0885-3924(99)00081-0)

Fig. 5 Variation of calcium blood levels over time. *Indicates statistically significant differences between all study time intervals and base line comparisons. **Indicates statistically significant differences between all study time interval comparisons Journal of Pain and Symptom Management 1999 18, 323-330DOI: (10.1016/S0885-3924(99)00081-0)