A Nonresponding Small Cell Lung Carcinoma

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Presentation transcript:

A Nonresponding Small Cell Lung Carcinoma Niels B. Pronk, MD, Albert J. Polman, MD, Lotus Sterk, MD, PhD, Jan W.A. Oosterhuis, MD, PhD, Egbert F. Smit, MD, PhD Journal of Thoracic Oncology Volume 4, Issue 10, Pages 1291-1292 (October 2009) DOI: 10.1097/JTO.0b013e3181b6b812 Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Small cell lung carcinoma. A, H&E staining with small cells with a high nuclear-cytoplasmic ratio, hyperchromatic polymorphous nuclei and no or inconspicuous nucleoli. In addition, numerous apoptotic cells. B, Ki-67 staining with about 40% of positive cells as a reflection of the high mitotic rate. Typical for SCLC is that the Ki-67 marker is at least positive in 25% of the cells.3 Journal of Thoracic Oncology 2009 4, 1291-1292DOI: (10.1097/JTO.0b013e3181b6b812) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Atypical carcinoid. A, H&E staining with solid sheets of cells grown in an organoid fashion separated by fibrous septa. The tumor cells have a high nuclear-cytoplasmic ratio, hyperchromatic fine granular polymorphous nuclei, and no or inconspicuous nucleoli. The mitosis index is 3/mm2 and apoptotic cells are rare. B, Ki-67 staining with less than 5% of positive cells, reflecting the relative low mitotic count. Journal of Thoracic Oncology 2009 4, 1291-1292DOI: (10.1097/JTO.0b013e3181b6b812) Copyright © 2009 International Association for the Study of Lung Cancer Terms and Conditions