T-cell receptor αβ+ and CD19+ cell–depleted haploidentical and mismatched hematopoietic stem cell transplantation in primary immune deficiency Ravi M.

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Presentation transcript:

T-cell receptor αβ+ and CD19+ cell–depleted haploidentical and mismatched hematopoietic stem cell transplantation in primary immune deficiency Ravi M. Shah, MD, DRCPSC, Reem Elfeky, MD, Zohreh Nademi, PhD, Waseem Qasim, MD, PhD, Persis Amrolia, PhD, FRCP, FRCPath, Robert Chiesa, MD, Kanchan Rao, MRCPCH, Giovanna Lucchini, MD, Juliana M.F. Silva, MD, Austen Worth, MD, PhD, Dawn Barge, PhD, David Ryan, DipSc, MSc, Jane Conn, MD, Andrew J. Cant, MD, Roderick Skinner, PhD, DCH, FRCPCH, Intan Juliana Abd Hamid, MD, Terence Flood, MD, Mario Abinun, MD, Sophie Hambleton, DPhil, Andrew R. Gennery, MD, Paul Veys, FRCP, FRCPath, Mary Slatter, MD Journal of Allergy and Clinical Immunology Volume 141, Issue 4, Pages 1417-1426.e1 (April 2018) DOI: 10.1016/j.jaci.2017.07.008 Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Survival according to CMV or adenovirus infection status on day 0. Journal of Allergy and Clinical Immunology 2018 141, 1417-1426.e1DOI: (10.1016/j.jaci.2017.07.008) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 CD4 and CD8 cell reconstitution after transplantation. Journal of Allergy and Clinical Immunology 2018 141, 1417-1426.e1DOI: (10.1016/j.jaci.2017.07.008) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Naive T-cell recovery. Journal of Allergy and Clinical Immunology 2018 141, 1417-1426.e1DOI: (10.1016/j.jaci.2017.07.008) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 B-cell (B cell–positive SCIDs excluded) and IgM recovery after transplantation. Journal of Allergy and Clinical Immunology 2018 141, 1417-1426.e1DOI: (10.1016/j.jaci.2017.07.008) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 αβ and γδ T-cell reconstitution after HSCT. Journal of Allergy and Clinical Immunology 2018 141, 1417-1426.e1DOI: (10.1016/j.jaci.2017.07.008) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions