Wilms' Tumor Gene 1 Transcript Levels in Leukapheresis of Peripheral Blood Hematopoietic Cells Predict Relapse Risk in Patients Autografted for Acute.

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Wilms' Tumor Gene 1 Transcript Levels in Leukapheresis of Peripheral Blood Hematopoietic Cells Predict Relapse Risk in Patients Autografted for Acute Myeloid Leukemia Carlo Messina, Anna Candoni, Matteo G. Carrabba, Cristina Tresoldi, Elisa Sala, Michela Tassara, Alessandra Crippa, Jacopo Peccatori, Andrea Assanelli, Salvatore Gattillo, Laura Bellio, Renato Fanin, Fabio Ciceri, Massimo Bernardi Biology of Blood and Marrow Transplantation Volume 20, Issue 10, Pages 1586-1591 (October 2014) DOI: 10.1016/j.bbmt.2014.06.017 Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Median LK-WT1 copy number (copies/ABL 10e4) of AML relapsed patients (right column, n = 14) and in those in continuous CR (left column, n = 16): 82 (range, 4 to 839) versus 13 (range, 4 to 109), respectively (P < .001). Biology of Blood and Marrow Transplantation 2014 20, 1586-1591DOI: (10.1016/j.bbmt.2014.06.017) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Cumulative incidence of relapse of 30 patients receiving autologous transplantation with apheresis containing ≥ 80 WT1 copies/ABL 10e4 (dotted line, n = 9) or <80 WT1 copies/ABL 10e4 (continuous line, n = 21), P = .0001. Biology of Blood and Marrow Transplantation 2014 20, 1586-1591DOI: (10.1016/j.bbmt.2014.06.017) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 DFS of 30 patients receiving autologous transplantation with apheresis containing ≥80 WT1 copies/ABL 10e4 (dotted line, n = 9) or <80 WT1 copies/ABL 10e4 (continuous line, n = 21), P = .0002. Biology of Blood and Marrow Transplantation 2014 20, 1586-1591DOI: (10.1016/j.bbmt.2014.06.017) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 OS of 30 patients receiving autologous transplantation with apheresis containing ≥80 WT1 copies/ABL 10e4 (dotted line, n = 9) or <80 WT1 copies/ABL 10e4 (continuous line, n = 21), P ≤ .0001. Biology of Blood and Marrow Transplantation 2014 20, 1586-1591DOI: (10.1016/j.bbmt.2014.06.017) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions