Ischemic preconditioning does not acutely improve load-insensitive parameters of contractility in in vivo stunned porcine myocardium M.Salik Jahania,

Slides:

Advertisements

Similar presentations

The additional hospital costs generated in the management of complications of pacemaker and defibrillator implantations T.Bruce Ferguson, MD, Candice Lilley.

Advertisements

L-Arginine, a nitric oxide precursor, attenuates ischemia-reperfusion injury by inhibiting inositol-1,4,5-triphosphate Tomohiro Mizuno, MD, Masazumi.

Manuel J. Antunes, MD, PhD, DSc

Inhaled nitric oxide reduces human lung allograft dysfunction

Myocardial protection with oxygenated esmolol cardioplegia during prolonged normothermic ischemia in the rat Ryuzo Bessho, MD, PhD, David J. Chambers,

Reduction of systolic and diastolic dysfunction by retrograde coronary sinus perfusion during off-pump coronary surgery Manuel Castellá, MD, Gerald D.

B. Zane Atkins, MD, Scott C. Silvestry, MD, Ravi N. Samy, MD, Ashish S

Esmolol and percutaneous cardiopulmonary bypass enhance myocardial salvage during ischemia in a dog model Glenn W. Laub, MD, S. Muralidharan, MD, Jerome.

Influence of oxygen in inflation gas during lung ischemia on ischemia-reperfusion injury Atsushi Watanabe, MD, Nobuyoshi Kawaharada, MD, Katsuyuki Kusajima,

The effect of ventricular volume reduction surgery in the dilated, poorly contractile left ventricle: A simple finite element analysis Mark B. Ratcliffe,

Akihiko Ohkado, MD, Hung Cao-Danh, PhD, K. Eric Sommers, MD, Pedro J

Combined endothelial and myocardial protection by endothelin antagonism enhances transplant allograft preservation Paul W.M. Fedak, MD, PhD, Vivek Rao,

Blood cardioplegia enhanced with nitric oxide donor SPM-5185 counteracts postischemic endothelial and ventricular dysfunction Katsuhiko Nakanishi, MD,

Basal nitric oxide expresses endogenous cardioprotection during reperfusion by inhibition of neutrophil-mediated damage after surgical revascularization

Daniel R. Meldrum, MD, Joseph C. Cleveland, MD, Brett C

Victor van Berkel, MD, PhD

Long-term myocardial preservation: effects of hyperkalemia, sodium channel, and NA+/K+/2CL- cotransport inhibition on extracellular potassium accumulation.

Shigeyuki Sasaki, MD, PhD (by invitation), James D

Studies of hypoxemic/reoxygenation injury with aortic clamping

The lord of the rings Antonio Miceli, MD, PhD

Continuous warm versus intermittent cold cardioplegic infusion: A comparison of energy metabolism, sodium-potassium adenosine triphosphatase activity,

Effects of cardioplegia on vascular function and the “no-reflow" phenomenon after ischemia and reperfusion: Studies in the isolated blood-perfused rat.

Intermittent aortic crossclamping prevents cumulative adenosine triphosphate depletion, ventricular fibrillation, and dysfunction (stunning): Is it preconditioning?

Effect of esophageal distention on pressure and electromyographic activity of the pharyngoesophageal sphincter, with identification of the esophagopharyngeal.

LV-powered coronary sinus retroperfusion reduces infarct size in acutely ischemic pigs Jeffrey S Martin, MD, John G Byrne, MD, Olivier Y Ghez, MD, Umer.

Editorial: The core of leadership

Does the degree of cyanosis affect myocardial adenosine triphosphate levels and function in children undergoing surgical procedures for congenital heart.

Physiologic Effects Of Extracellular Superoxide Dismutase Transgene Overexpression On Myocardial Function After Ischemia And Reperfusion Injury Edward.

Myocyte and endothelial effects of preconditioning the jeopardized heart by inhibiting Na+/H+ exchange Manuel Castellá, MDa, Gerald D. Buckberg, MDa,

Support Your Specialty

Exogenous magnesium chloride-adenosine triphosphate administration during reperfusion reduces the extent of necrosis in previously ischemic skeletal muscle

Ashok Muniappan, MD The Journal of Thoracic and Cardiovascular Surgery

Elucidation of a tripartite mechanism underlying the improvement in cardiac tolerance to ischemia by coenzyme Q10 pretreatment Juan A. Crestanello, MD.

Cardioplegia and vascular injury

Dysfunction induced by ischemia versus edema: Does edema matter?

Tissue concentrations of endothelins and functional effects of endothelin-receptor activation in human arteries and veins Peter Holm, MD, Anders Franco-Cereceda,

Experimental study of intermittent crossclamping with fibrillation and myocardial protection: Reduced injury from shorter cumulative ischemia or intrinsic.

Ischemic preconditioning with opening of mitochondrial adenosine triphosphate– sensitive potassium channels or Na+/H+ exchange inhibition: Which is the.

Aging reduces postischemic recovery of coronary endothelial function

REVERSAL OF IATROGENIC MYOCARDIAL EDEMA AND RELATED ABNORMALITIES OF DIASTOLIC PROPERTIES IN THE PIG LEFT VENTRICLE David A. Dean, MDa*, Mehrdad M. Amirhamzeh,

Ischemic postconditioning promotes left ventricular functional recovery after cardioplegic arrest in an in vivo piglet model of global ischemia reperfusion.

Michael Kronon, MD. , Kirk S. Bolling, MD, Bradley S

Attachment disorder in thoracoabdominal surgery

Patient recovery after intermittent disc escape and spontaneous recession of a mechanical heart valve Francis Robicsek, MD, PhD, Joseph W. Cook, MD

Kai Ihnken, MD The Journal of Thoracic and Cardiovascular Surgery

Addition Of A Mast Cell Stabilizing Compound To Organ Preservation Solutions Decreases Lung Reperfusion Injury Mark L. Barr, MD, Joseph N. Carey, BS,

Elspeth M. Brown, MRCP, Anthony P. Salmon, FRCP, Robert K. Lamb, FRCS

Preconditioning improves cardioplegia-related coronary microvascular smooth muscle hypercontractility: Role of KATP channels Naruto Matsuda, MD, PhDa,

Reactive hyperemia during early reperfusion as a determinant of improved functional recovery in ischemic preconditioned rat hearts Annie Rochetaing,

Adenosine-enhanced ischemic preconditioning provides myocardial protection equal to that of cold blood cardioplegia James D McCully, PhD, Masahisa Uematsu,

Myocardial stunning: A therapeutic conundrum

Simultaneous Antegrade And Retrograde Delivery Of Continuous Warm Blood Cardioplegia After Global Ischemia Anders B. Ericsson, MD, Shigeto Takeshima,

The Journal of Thoracic and Cardiovascular Surgery

Discussion The Journal of Thoracic and Cardiovascular Surgery

The future of cardiac surgery training: A survival guide

Avoiding reperfusion injury after limb revascularization: Experimental observations and recommendations for clinical application Friedhelm Beyersdorf,

Atrial natiuretic peptide release at rest and with exercise after cardiac transplantation with bicaval anastomoses Andres W. Jahnke, MD*, Rainer Leyh,

Michael T. Kronon, MD, Bradley S

L-arginine, prostaglandin, and white cell filtration equally improve myocardial protection in stressed neonatal hearts Michael T. Kronon, MD, Bradley.

Early effects of hypothyroidism on the contractile function of the rat heart and its tolerance to hypothermic ischemia Manuel Galiñanes, MD, PhD, Ryszard.

Commentary: A paradox of remote ischemic preconditioning: Remote understanding, remote relevance, and remote future? Tyson A. Fricke, MBBS, BMedSci,

Myocardial protection by ischemic preconditioning and δ-opioid receptor activation in the isolated working rat heart Matthias Karck, MDa, Satonori Tanaka,

Insulin-induced improvement of postischemic recovery is abolished by inhibition of protein kinase C in rat heart Ulrich Fischer-Rasokat, BS, Torsten.

Toll-like receptor 4 inhibition attenuates ischemia-reperfusion injury in rats: Will it work in human beings? Chadrick E. Denlinger, MD The Journal.

Managing conflicts of interest

Modulation of myocardial perfusion and vascular reactivity by pericardial basic fibroblast growth factor: Insight into ischemia-induced reduction in endothelium-dependent.

Systemic hypothermia and circulatory arrest combined with arterial perfusion of the superior vena cava Bruce W. Lytle, MD, Patrick M. McCarthy, MD, Kevin.

Randy M. Stevens, MD, M. Salik Jahania, MD, Robert M

Effects of in vivo myocardial ischemia and reperfusion on interstitial nitric oxide metabolites Randy M Stevens, MD, M.Salik Jahania, MD, Jennifer E.

Contribution of hyperoxia to lipid peroxidation in coronary artery operations: Should we keep a low oxygen tension? Leonidas Hadjinikolaou, MD, Andrew.

Presentation transcript:

Ischemic preconditioning does not acutely improve load-insensitive parameters of contractility in in vivo stunned porcine myocardium M.Salik Jahania, MD, Robert D. Lasley, PhD, Robert M. Mentzer, MD The Journal of Thoracic and Cardiovascular Surgery Volume 117, Issue 4, Pages 810-817 (April 1999) DOI: 10.1016/S0022-5223(99)70303-X Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig 1 The effects of ischemic preconditioning (IPC) on baseline segment shortening (%SS) and SW in the LAD bed. IPC1 and IPC2 refer to values obtained after 10 minutes of reperfusion after the first (IPC1) and second (IPC2) 5-minute LAD occlusions. *P < .01 versus baseline. The Journal of Thoracic and Cardiovascular Surgery 1999 117, 810-817DOI: (10.1016/S0022-5223(99)70303-X) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig 3 Baseline and reperfusion (RP) SW values in the LAD-perfused bed. The baseline SW in the ischemic preconditioning (IPC) group is the value after the preconditioning occlusions but before the 15-minute ischemia (not significantly different from its baseline value, P = .16). *P < .05 versus baseline; #P = .01 versus control group. The Journal of Thoracic and Cardiovascular Surgery 1999 117, 810-817DOI: (10.1016/S0022-5223(99)70303-X) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig 2 Recovery of segment shortening (SS) in control and ischemic preconditioning (IPC) groups after 15 minutes of LAD occlusion. Values are expressed as percent recovery of baseline segment shortening at 1, 2, and 3 hours of reperfusion (RP). The recovery of segment shortening in the IPC groups is expressed as percent of segment shortening values before the IPC protocol. All values are statistically different from preischemic values. *P < .05 versus baseline. The Journal of Thoracic and Cardiovascular Surgery 1999 117, 810-817DOI: (10.1016/S0022-5223(99)70303-X) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig 4 Values of the slope (Ees; A) and length axis intercept at a pressure of 70 mm Hg (L70; B) in control and ischemic preconditioned pigs. Ees and L70 were calculated from the ESPLR generated during brief vena cava occlusions. *P < .05 versus baseline. The Journal of Thoracic and Cardiovascular Surgery 1999 117, 810-817DOI: (10.1016/S0022-5223(99)70303-X) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig 5 Effects of ischemic preconditioning (IPC) on PRSW in stunned myocardium. PRSW is based on the slope (A) and length axis intercept (LPRSW; B) of PRSW calculated from data generated during brief vena cava occlusions. *P < .05 versus baseline. The Journal of Thoracic and Cardiovascular Surgery 1999 117, 810-817DOI: (10.1016/S0022-5223(99)70303-X) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig 6 PRSWA in the LAD-perfused bed in control and ischemic preconditioned (IPC) groups. PRSWA was calculated as described by Glower and colleagues.24 *P < .05 versus baseline. The Journal of Thoracic and Cardiovascular Surgery 1999 117, 810-817DOI: (10.1016/S0022-5223(99)70303-X) Copyright © 1999 Mosby, Inc. Terms and Conditions