Fig. 1. Specificity of FolamiR uptake in cancer cells in culture.

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Fig. 1. Specificity of FolamiR uptake in cancer cells in culture. Specificity of FolamiR uptake in cancer cells in culture. (A) Proposed mechanism of action of FolamiRs. (B) Identification of FRα in FR+ MB-231 breast cancer cells and in FR− A549 lung cancer cells. Histograms represent overlaid flow cytometry data as a percentage of unstained, FRα+, and isotype control–stained cells. (C) NIR-FolamiR-34a uptake in FR+ MB-231 cells compared to FR− A549 cells. Histograms represent overlaid flow cytometry data as a percentage of unstained and NIR-FolamiR-34a (50 nM)–stained cells. (D) Fol-FITC uptake in FR+ MB-231 cells compared to FR− A549 cells. Scale bars, 50 μm. (E) Targeted silencing of miR-34a Renilla sensor using FolamiR in MB-231 and A549 cells in vitro. Data points were normalized to FolamiR-NC (negative control: scrambled miRNA) for each time point. Error bars: means ± SD. Each experiment corresponds to n = 3 with at least four technical replicates per treatment. **P < 0.01, *P < 0.05, one-way analysis of variance (ANOVA) and Bonferroni correction. ns, not significant. Esteban A. Orellana et al., Sci Transl Med 2017;9:eaam9327 Published by AAAS