Valproic acid (VPA) modulates expression of genes involved in cell death pathways. Valproic acid (VPA) modulates expression of genes involved in cell death.

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Valproic acid (VPA) modulates expression of genes involved in cell death pathways. Valproic acid (VPA) modulates expression of genes involved in cell death pathways. Genes transcriptionally modified by VPA extrated from the online supplementary material were analysed with the Ingenuity software. The most significantly affected molecular and cellular function was cell death (p<3.89×10−0.5, with 54 genes modulated: ADRB2, ALX3, ARC, BAG3, BBC3, BCL6, CNN2, CYP26B1, DLL1, DLX2, DUSP10, EGR1, EGR4, EPHA2, FBXO32, FOXO1, GAS2, GDF15, GFI1, GJB2, GPC3, GPR37, HEY1, IER3, IL9R, JAG1, KLF2, KLF5, LATS2, MERTK, MITF, NKX3-2, NR4A2, NTF3, NUAK2, PAX6, PDGFRA, PPARA, RASD1, RASSF4, RUNX1, RUNX1T1, S100A10, SGK1, SIRT4, SOCS3, SSTR2, TNFRSF19, TNFRSF12A, TSLP, USE1, VIPR2, WNT11 and ZFP36). Red and green indicate up- and down-regulated genes, respectively. Roland Hubaux et al. ERJ Open Res 2015;1:00028-2015 ©2015 by European Respiratory Society