Valproic acid (VPA) modulates expression of genes involved in cell death pathways. Valproic acid (VPA) modulates expression of genes involved in cell death.

Slides:



Advertisements
Similar presentations
A B C Supplementary Figure S1. Trabectedin decreases viability of primary MPM cell cultures. A and B, dose-dependent impact of trabectedin on epithelioid.
Advertisements

Representation of the 15 selected premature termination codons (PTCs) and their corresponding recoded major protein. Representation of the 15 selected.
Fusion genes in cord blood
p53 and Apoptosis: It's Not Just in the Nucleus Anymore
The 20-year overall survival was significantly higher in the newborn screening (NBS) group than in the symptoms group for each of the subgroups defined.
Echocardiography view
Compliance of the respiratory system (Crs) at baseline and 0 h, 1 h and 2 h following lung volume recruitment. a) Absolute Crs in the respiratory muscle.
IRF4 regulates cytokine receptor expression in CD8+ T cells.
Distribution of forced expiratory volume in 1 s (FEV1) relative to Global Lung Function Initiative reference values (GLI2012) [10] expressed as FEV1 %
Dried blood spot for therapeutic drug monitoring. a).
Composition of microbial communities in induced sputa of healthy and mild, moderate, severe or very severe (end-stage) lung disease affected individuals.
A) CT scan of patient number 1, before pembrolizumab; b) CT scan of patient number 1, after 11 pembrolizumab infusions; c) CT scan of patient number 1,
Survival without tracheostomy
Readthrough levels measured for the indicated cystic fibrosis transmembrane conductance regulator (CFTR) premature termination codon mutations, at basal.
Symptoms measured by Edmonton Symptom Assessment Scale according to modified Medical Research Council (mMRC) dyspnoea scale groups. Symptoms measured by.
The correlation between Mycobacterium growth indicator tube (MGIT) time to culture positivity (TTP) and bacterial load count by molecular bacterial load.
Kaplan–Meier curve for the time until the development of lung cancer in patients with idiopathic pulmonary fibrosis. Kaplan–Meier curve for the time until.
MRNA expression of collagen-binding integrins in idiopathic pulmonary fibrosis (IPF) lungs. mRNA expression of collagen-binding integrins in idiopathic.
Bland–Altman plot of slopes of measurement 1 versus 2
Bland–Altman comparison of lung clearance index (LCI) from multiple breath wash-out following open and modified closed circuit wash-in for both healthy.
Function of recoded cystic fibrosis transmembrane conductance regulator (CFTR) channels. a) Representative recordings obtained from HEK293 cells expressing.
Maturation of recoded cystic fibrosis transmembrane conductance regulator (CFTR) channels. a) Representative Western blot obtained from HEK293 cells expressing.
Lung interleukin (IL)-33 protein expression in vivo depends on caspase-1. Lung interleukin (IL)-33 protein expression in vivo depends on caspase-1. Mice.
Caspase-1 deficient mice have a lower expression of lung T-helper type 2 (Th2)-upstream cytokines at exacerbation. Caspase-1 deficient mice have a lower.
Kaplan–Meier survival curves of all-cause mortality in patients with idiopathic pulmonary fibrosis (IPF). Kaplan–Meier survival curves of all-cause mortality.
In vitro quantification of exon skipping associated with 15 premature termination codons using minigenes. In vitro quantification of exon skipping associated.
Lipoxin A4 (LXA4) up-regulates aquaporin 5 (AQP5) and downregulates surfactant protein C but has no effect on receptor for advanced glycation end products.
Usability statistics among active users of the national tuberculosis (TB) registry by TB burden. Usability statistics among active users of the national.
A white elephant or the elephant in the room
Cluster analysis and pathway-based characterization of differentially expressed genes and proteins from integrated proteomics. Cluster analysis and pathway-based.
Rhinovirus (RV) infection induces caspase-1 expression in bronchial epithelial cells in asthma. Rhinovirus (RV) infection induces caspase-1 expression.
The variability of probability of that the length of stay is longer than the median by country. The variability of probability of that the length of stay.
K-Means clustering of protein and mRNA expression patterns after PPAR agonists treatments. k-Means clustering of protein and mRNA expression patterns after.
Functional interaction network based on the 234 differentially expressed genes. a) Functional network with annotated gene clusters. Functional interaction.
Most frequent words and phrases based on user comments about the registry. Most frequent words and phrases based on user comments about the registry. Word.
Transcriptionally regulated genes in Δsaci_ptp and Δsaci_pp2a as compared with the strain MW001. Transcriptionally regulated genes in Δsaci_ptp and Δsaci_pp2a.
Bar plot representation of the transcriptomic changes in Δsaci_ptp and Δsaci_pp2a. Bar plot representation of the transcriptomic changes in Δsaci_ptp and.
Usability statistics among top 10 tuberculosis (TB) units by transaction type for key data fields. Usability statistics among top 10 tuberculosis (TB)
Systems biology as a tool to improve idiopathic pulmonary fibrosis (IPF) treatment effectiveness. Systems biology as a tool to improve idiopathic pulmonary.
a) Mortality per time point (p<0
Regulation of clusters in human datasets
Clusters from the functional network
Protein expression profiling of small cell lung carcinoma treated with valproic acid (VPA) and VAC (mafosfamide, doxorubicin and vindesine). Protein expression.
Measurement of a) IL-8, b) IL-6 and c) GM-CSF release by BEAS-2B cells stimulated with deoxycholic acid for 48 h. Measurement of a) IL-8, b) IL-6 and c)
Valproic acid (VPA) synergises with VAC (mafosfamide, doxorubicin and vindesine) to induce apoptosis in small cell lung carcinoma (SCLC) cell lines. Valproic.
Differential protein, mRNA, lncRNA and miRNA regulation by p53.
Treatment with DM-α-KG rescues gene expression in the context of chronic mtDNA depletion. Treatment with DM-α-KG rescues gene expression in the context.
Valproic acid (VPA) prevents small cell lung carcinoma (SCLC) tumour growth in combination with cyclophosphamide, vindesine and doxorubicin. Valproic acid.
Forest plot of adjusted odds ratios (with 95% confidence intervals) from multivariable multinomial logistic regression analysis (table 4), by number of.
Concordance of review article recommendations with contemporary guidelines. Concordance of review article recommendations with contemporary guidelines.
Ingenuity pathway analysis of the genes enriched in both 96-h-induced MMs and human ccRCC. Ingenuity pathway analysis of the genes enriched in both 96-h-induced.
Weekly pneumococcal community-acquired pneumonia incidence rates over 5 years, with delineated school holiday periods by year. a) Year 1 (September 2008–2009).
Analysis of renal transcriptome responses identifies LX-regulated transcriptional networks. Analysis of renal transcriptome responses identifies LX-regulated.
Diagram of rebreathe apparatus.
Differences in a) functional residual capacity (FRC) and b) lung clearance index (LCI) when using all trials in comparison with only the first two trials.
Distribution of patients in the first- or second-year follow-up according to the number of acute exacerbations of chronic obstructive pulmonary disease.
Bland–Altman comparison of functional residual capacity (FRC) measured from multiple breath wash-out following open and modified closed circuit wash-in.
The pulmonary microbiome of children with persistent bacterial bronchitis (PBB). The pulmonary microbiome of children with persistent bacterial bronchitis.
Usability statistics among active users of the national tuberculosis (TB) registry by TB burden. Usability statistics among active users of the national.
M-Wnt and E-Wnt cells cluster tightly with claudin-low and basal-like breast tumors, respectively, by microarray analysis. M-Wnt and E-Wnt cells cluster.
Activation of Wnt signaling pathway in trastuzumab-resistant cell lines. Activation of Wnt signaling pathway in trastuzumab-resistant cell lines. A, bar.
A) Schematic diagram of the function principles of a noninvasive mechanical ventilator. b) Diagram of conventional noninvasive mechanical ventilators.
Composition of the most common clusters at the a) onset of the first acute respiratory tract infection (swab A) and b) 3 weeks later (swab B) illustrated.
RUNX3 depletion induces cellular senescence and inflammatory cytokine expression in cells undergoing TGFβ-mediated EMT. A, Cells were transfected with.
Comparison of cancer-specific survival in patients with nonsmall cell lung cancer detected incidentally by computed tomography (CT) (n=41) or chest radiography.
Percentage of positive results by pathogen among study patients with identified pathogens. “Other” includes respiratory viruses, Stenotrophomonas, Prevotella,
Differential pathway regulation in advanced idiopathic pulmonary fibrosis (IPF) lung. a) Metacore analyses of pathway enrichment in IPF versus control.
Bioinformatic analyses suggest that PI3K/AKT signaling may be a key downstream pathway of tazarotene signaling. Bioinformatic analyses suggest that PI3K/AKT.
Median (95% CI) exhaled nitric oxide fraction (FeNO) at each visit for the two intervention groups. Median (95% CI) exhaled nitric oxide fraction (FeNO)
Geometric mean (95% CI) response dose ratio (RDR) at each visit for the two intervention groups. Geometric mean (95% CI) response dose ratio (RDR) at each.
Presentation transcript:

Valproic acid (VPA) modulates expression of genes involved in cell death pathways. Valproic acid (VPA) modulates expression of genes involved in cell death pathways. Genes transcriptionally modified by VPA extrated from the online supplementary material were analysed with the Ingenuity software. The most significantly affected molecular and cellular function was cell death (p<3.89×10−0.5, with 54 genes modulated: ADRB2, ALX3, ARC, BAG3, BBC3, BCL6, CNN2, CYP26B1, DLL1, DLX2, DUSP10, EGR1, EGR4, EPHA2, FBXO32, FOXO1, GAS2, GDF15, GFI1, GJB2, GPC3, GPR37, HEY1, IER3, IL9R, JAG1, KLF2, KLF5, LATS2, MERTK, MITF, NKX3-2, NR4A2, NTF3, NUAK2, PAX6, PDGFRA, PPARA, RASD1, RASSF4, RUNX1, RUNX1T1, S100A10, SGK1, SIRT4, SOCS3, SSTR2, TNFRSF19, TNFRSF12A, TSLP, USE1, VIPR2, WNT11 and ZFP36). Red and green indicate up- and down-regulated genes, respectively. Roland Hubaux et al. ERJ Open Res 2015;1:00028-2015 ©2015 by European Respiratory Society