Etifoxine modulation of T‐cell activity during EAE

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Presentation transcript:

Etifoxine modulation of T‐cell activity during EAE Etifoxine modulation of T‐cell activity during EAE. Spinal cords of vehicle‐ or etifoxine‐treated mice were either used for flow cytometry analysis or ELISA analysis. Etifoxine modulation of T‐cell activity during EAE. Spinal cords of vehicle‐ or etifoxine‐treated mice were either used for flow cytometry analysis or ELISA analysis. Cells stained for CD4, CD8, IL‐17 and IFN‐γ were gated according to fluorescent intensity.A.Cells were then measured as a percentage of the total cell population. There was a decrease in the percentage of CD4+ (*p = 0.04), CD4+/IL‐17+ (*p = 0.04), CD8+ (*p = 0.01) and CD8+/IFNγ+ (*p = 0.03) cells in the drug‐treated groupB.Protein levels of the inflammatory cytokines IL‐1β (*p = 0.001), IL‐17 (*p = 0.02) and IFN‐γ (*p = 0.02) were also measured, and there was a significant decrease in all cytokines in response to etifoxine treatmentC.The p‐values were calculated using t‐test, n = 8/group. Daniel J. Daugherty et al. EMBO Mol Med. 2013;5:891-903 © as stated in the article, figure or figure legend