Food For Thought: Neural Stem Cells on a Diet

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Presentation transcript:

Food For Thought: Neural Stem Cells on a Diet Elizabeth T. Ables, Daniela Drummond-Barbosa Cell Stem Cell Volume 8, Issue 4, Pages 352-354 (April 2011) DOI: 10.1016/j.stem.2011.03.004 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 Dietary Stem Cell Regulation in Drosophila (A) In larvae, fat body TOR-mediated amino acid sensing induces a secreted fat body-derived signal (FDS) that activates glial insulin-like peptide (ILP) expression. Glial ILPs act on adjacent neuroblasts via insulin/PI3K/TOR signaling to control reactivation. The same or another FDS activates median neurosecretory cell (mNSC) ILP production. (B) In adults, diet-dependent mNSC ILPs activate insulin/PI3K signaling in intestinal stem cells (ISCs) and germline stem cells (GSCs), and ILPs also affect the female GSC niche. FDSs might have direct or indirect effects on other growing tissues or adult stem cells. Solid lines, known signals; dashed lines, hypothetical relays. Cell Stem Cell 2011 8, 352-354DOI: (10.1016/j.stem.2011.03.004) Copyright © 2011 Elsevier Inc. Terms and Conditions