R.A. Armstrong, P.L. Lantos, N.J. Cairns Pathophysiology

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The spatial patterns of pathological brain lesions in 12 patients with corticobasal degeneration R.A. Armstrong, P.L. Lantos, N.J. Cairns Pathophysiology Volume 8, Issue 1, Pages 47-53 (August 2001) DOI: 10.1016/S0928-4680(00)00060-2

Fig. 1 Examples of clusters of lesions in individual brain regions in patients with corticobasal degeneration: (a) a small cluster of tau+ BN approximately 200 μm in diameter; (b) a part of a larger cluster of more weakly stained BN, the total size of the cluster was approximately 1600 μm; (c) a cluster of tau+ neurons with inclusions approximately 300 μm in diameter (scale bar 50 μm). Pathophysiology 2001 8, 47-53DOI: (10.1016/S0928-4680(00)00060-2)

Fig. 1 Examples of clusters of lesions in individual brain regions in patients with corticobasal degeneration: (a) a small cluster of tau+ BN approximately 200 μm in diameter; (b) a part of a larger cluster of more weakly stained BN, the total size of the cluster was approximately 1600 μm; (c) a cluster of tau+ neurons with inclusions approximately 300 μm in diameter (scale bar 50 μm). Pathophysiology 2001 8, 47-53DOI: (10.1016/S0928-4680(00)00060-2)

Fig. 2 Examples of pattern analysis plots showing the spatial patterns exhibited by lesions in individual areas of the cerebral cortex of patients with corticobasal degeneration (a) ballooned neurons (BN) in the frontal cortex; (b) tau positive neurons with inclusion bodies (tau+ neurons) in the frontal cortex; (c) tau+ plaques. Arrows indicate the presence of significant peaks. Pathophysiology 2001 8, 47-53DOI: (10.1016/S0928-4680(00)00060-2)

Fig. 3 The size (μm) of the clusters of ballooned neurons, tau positive neurons with inclusions (tau+ neurons) and tau positive plaques, averaged over patients, in the upper and lower cortical laminae (FC, frontal cortex; PC, parietal cortex; STG, superior temporal gyrus; PHG, parahippocampal gyrus) in cases of corticobasal degeneration (bars indicate standard errors. Analysis of variance (two factor, split-plot) (*P<0.05): BN, Brain region F=0.27 (P>0.05), upper cortex versus lower cortex F=1.61 (P>0.05), interaction F=3.25 (P<0.05); tau+ neurons brain region F=0.78 (P>0.05), upper cortex versus lower cortex F=4.17 (P<0.05), interaction F=0.65 (P>0.05). Pathophysiology 2001 8, 47-53DOI: (10.1016/S0928-4680(00)00060-2)