Augmentation of UVB Radiation-Mediated Early Gene Expression by the Epidermal Platelet-Activating Factor Receptor Jeffrey B. Travers, Howard J. Edenberg,

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Augmentation of UVB Radiation-Mediated Early Gene Expression by the Epidermal Platelet-Activating Factor Receptor Jeffrey B. Travers, Howard J. Edenberg, Qiwei Zhang, Mohammed Al-Hassani, Qiaofang Yi, Sulochanadevi Baskaran, Raymond L. Konger Journal of Investigative Dermatology Volume 128, Issue 2, Pages 455-460 (February 2008) DOI: 10.1038/sj.jid.5701083 Copyright © 2008 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Effect of PAF-R agonist or UVB irradiation on CCL20 protein levels in KB cells. KBM and KBP cells were treated with 100nM of the PAF-R agonist CPAF, 1μm of the phorbol ester phorbol 12-myristate 13-acetate, vehicle control, or irradiation with 400J/m2 with UVB. The supernatants were removed 6hours later and CCL20 protein measured by ELISA. Cell density was assessed by counting. The values are mean±SD pg CCL20 per 106 cells of a typical experiment using duplicate samples from at least four separate experiments. Journal of Investigative Dermatology 2008 128, 455-460DOI: (10.1038/sj.jid.5701083) Copyright © 2008 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Effect of PAF-R agonist on cytokine mRNA levels in vivo. Skin of wild-type or PAF-R−/− mice was injected with BSA vehicle, 100ng CPAF, or irradiated with 1,200J/m2 UVB. After 8hours, the skin was harvested and RNA extracted and subjected to quantitative real-time RT-PCR. The values are mean±SE mRNA levels of (a) TNF-α and (b) CCL20 normalized to 18S ribosomal RNA from duplicate samples and are derived from four mice of each genotype. *Denotes statistically significant (P<0.05 using paired Student's t-test) decreases in cytokine mRNA in PAF-R−/− mice in comparison with wild-type counterparts. Journal of Investigative Dermatology 2008 128, 455-460DOI: (10.1038/sj.jid.5701083) Copyright © 2008 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Effect of PAF-R agonist on cytokine protein levels in vivo. Skin of wild-type or PAF-R−/− mice was injected with BSA vehicle, 100ng CPAF, or irradiated with 1,200J/m2 UVB. After 8hours, the skin was harvested and subjected to immunohistochemistry to measure (a) TNF-α and (b) CCL20. The above are representative of findings from four mice of each genotype. Journal of Investigative Dermatology 2008 128, 455-460DOI: (10.1038/sj.jid.5701083) Copyright © 2008 The Society for Investigative Dermatology, Inc Terms and Conditions