Low exposure to melamine increases the risk of urolithiasis in adults

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Low exposure to melamine increases the risk of urolithiasis in adults Chia-Chu Liu, Chia-Fang Wu, Bai-Hsiun Chen, Shu-Pin Huang, William Goggins, Hei-Hwa Lee, Yii-Her Chou, Wen-Jeng Wu, Chun- Hsiung Huang, Jentaie Shiea, Chien-Hung Lee, Kuen-Yuh Wu, Ming-Tsang Wu Kidney International Volume 80, Issue 7, Pages 746-752 (October 2011) DOI: 10.1038/ki.2011.154 Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 1 One representative spectrum of melamine content in the stone specimen from one calcium stone patient with urinary melamine level of 1.58ng/ml by the technique of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS and MS/MS). (a) Standard of one melamine cyanurate synthetic stone showing melamine signal of (M+H)+ at m/z 127 by MALDI mass spectra (upper); one real stone specimen (middle); the blank in MALDI matrix 2,5-dihydroxybenzoic acid (DHB) solution (lower). (b) MALDI tandem mass spectra of the ions at m/z 127 to 85 in standard of melamine cyanurate synthetic stone (upper) and real stone specimen (lower). Kidney International 2011 80, 746-752DOI: (10.1038/ki.2011.154) Copyright © 2011 International Society of Nephrology Terms and Conditions