Platelets are required for hFcγRIIA-induced anaphylaxis.

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Platelets are required for hFcγRIIA-induced anaphylaxis. Platelets are required for hFcγRIIA-induced anaphylaxis. (A and B) Change in body temperature (left) and platelet count (right) during HA-hIgG–dependent anaphylaxis in hFcγRIIAtg (circles, n = 4) and FcγRnull (squares, n = 4) mice. (C) HA-hIgG–dependent anaphylaxis–induced changes in body temperature in hFcγRIIAtg (circles) and FcγRnull (squares) mice (n = 4), pretreated with anti-GPIbα antibody (red symbols) or isotype control (black symbols, n = 4). (D) Platelet counts in hFcγRIIAtg (circles) and FcγRnull (squares) mice, pretreated (green symbols, n = 5) or not (open symbols, n = 4 or 5) with romiplostim. (E) Change in body temperature (left) and survival (right) during HA-hIgG–dependent anaphylaxis in hFcγRIIAtg (circles) and FcγRnull (squares) mice pretreated (green symbols) or not (open symbols) with romiplostim (n = 3). ↓: Death of all romiplostim-treated hFcγRIIAtg mice before the first temperature readout. (A to E) Temperature data are means ± SEM, and platelet counts from individual mice are indicated together with the means ± SEM. Data in (A) to (E) are representative of at least two independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001. Héloïse Beutier et al. Sci. Immunol. 2018;3:eaan5997 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works