Volume 68, Issue 4, Pages (October 2005)

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Volume 68, Issue 4, Pages 1888-1893 (October 2005) Low calorie commercial sugar is a sensitive marker of glomerular filtration rate Jazmin M. Pérez-Rojas, Jorge A. Blanco, Gerardo Gamba, Norma A. Bobadilla Kidney International Volume 68, Issue 4, Pages 1888-1893 (October 2005) DOI: 10.1111/j.1523-1755.2005.00609.x Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 1 Representative standard curves for LC sugar concentrations by using anthrone reagent. Two sets of standards were made. Linear regression and correlation were calculated by the least-squares method and the values represent the mean value of each concentration ± standard deviation. Kidney International 2005 68, 1888-1893DOI: (10.1111/j.1523-1755.2005.00609.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 2 Mean arterial pressure and renal blood flow was recorded in nontreated rats (white bars) and in CsA treated rats (black bars) infused with inutest or LC sugar as markers of glomerular filtration rate. The results are expressed as means ± standard error. Statistical comparisons between experimental groups were performed by using ANOVA and Student-Newman-Keuls test. *P < 0.05 vs. their respective nontreated groups. Kidney International 2005 68, 1888-1893DOI: (10.1111/j.1523-1755.2005.00609.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 3 Creatinine clearance in nontreated rats (white circles) and in CsA treated rats (black circles) that were used in inulin or LC sugar groups. Individual values are showed in the graph. Horizontal lines represent the mean value for each group. Statistical comparisons between experimental groups were performed by using ANOVA and Student-Newman-Keuls test. *P < 0.05 vs. their respective nontreated groups. Kidney International 2005 68, 1888-1893DOI: (10.1111/j.1523-1755.2005.00609.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 4 Inutest and LC sugar were used as markers of glomerular filtration rate, white circles represent the values of GFR in nontreated rats and the black circles the GFR values in CsA treated rats. Horizontal lines represent the mean value for each group. Statistical comparisons between experimental groups were performed by using ANOVA and Student-Newman-Keuls test. *P < 0.05 vs. their respective nontreated groups. Kidney International 2005 68, 1888-1893DOI: (10.1111/j.1523-1755.2005.00609.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 5 Effect of increasing LC sugar concentrations infusion on (A) LC sugar plasma concentration and (B) glomerular filtration rate in nontreated rats. Each point represents mean value from 6 different rats ± standard error. Statistical comparison was performed by using repeated measures ANOVA and Student-Newman-Keuls test. *P < 0.05 vs. 5% LC sugar infusion period, **P < 0.05 vs. 7.5% LC sugar infusion period, and ***P < 0.05 vs. 10% LC sugar infusion period. Kidney International 2005 68, 1888-1893DOI: (10.1111/j.1523-1755.2005.00609.x) Copyright © 2005 International Society of Nephrology Terms and Conditions