Michelle Daya, PhD, Kathleen C. Barnes, PhD

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Presentation transcript:

Identification of novel allergic diathesis genes: Are we closer to novel therapeutic targets? Michelle Daya, PhD, Kathleen C. Barnes, PhD Journal of Allergy and Clinical Immunology Volume 143, Issue 2, Pages 557-559 (February 2019) DOI: 10.1016/j.jaci.2018.11.028 Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 GWAS Manhattan plot of the shared genetic origin of asthma, hay fever, and eczema in subjects. The plot summarizes single nucleotide polymorphism association statistics from the previous meta-analysis and illustrate the strong association peaks that can be obtained through team science and large sample sizes. Before applying the EUGENE method, a conditional analysis was performed to remove the main effects of the previous meta-analysis to discover additional genetic underpinnings of allergy. The location of the new genes discovered by using EUGENE is highlighted. Only 1 of the gene regions has a single SNP association that crosses genome-wide significance. Journal of Allergy and Clinical Immunology 2019 143, 557-559DOI: (10.1016/j.jaci.2018.11.028) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions