Kinesin-5: A Team Is Just the Sum of Its Parts

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Kinesin-5: A Team Is Just the Sum of Its Parts Christina L. Hueschen, Alexandra F. Long, Sophie Dumont Developmental Cell Volume 34, Issue 6, Pages 609-610 (September 2015) DOI: 10.1016/j.devcel.2015.09.010 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Microtubule Overlap Length Regulates Active Force Generation Shimamoto, Forth, and Kapoor (2015) use an in vitro assay to map how microtubule architecture regulates force generation by kinesin-5 ensembles, dissecting two minimal architectural modules in the spindle. They show that motors linking antiparallel microtubules (green) generate pushing forces that scale with microtubule overlap and motor number and that motors linking parallel microtubules (red) can exert braking forces with the same scaling. Thus, for the numbers of kinesin-5 (people) probed, the force (weight lifted) generated by each motor is independent of the total number of motors acting in the team. Developmental Cell 2015 34, 609-610DOI: (10.1016/j.devcel.2015.09.010) Copyright © 2015 Elsevier Inc. Terms and Conditions