Cutaneous inflammatory cell infiltrate in chronic idiopathic urticaria: Comparison of patients with and without anti-FcϵRI or anti-IgE autoantibodies

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Presentation transcript:

Cutaneous inflammatory cell infiltrate in chronic idiopathic urticaria: Comparison of patients with and without anti-FcϵRI or anti-IgE autoantibodies Ruth A. Sabroe, MRCP, Eric Poon, MB, BS, Guy E. Orchard, MSc FIBMS, David Lane, David M. Francis, BSc, Robert M. Barr, PhD, Martin M. Black, MD, FRCP, FRCPath, Anne Kobza Black, MD, FRCP, Malcolm W. Greaves, MD, PhD, FRCP Journal of Allergy and Clinical Immunology Volume 103, Issue 3, Pages 484-493 (March 1999) DOI: 10.1016/S0091-6749(99)70475-6 Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 1 Percentage histamine release from basophils of 2 healthy donors induced by serum of 22 patients with CIU. The graph indicates how patients with CIU were divided into 2 groups: those with serum that released 5% or greater histamine from the basophils of one or both donors and those with serum that did not release histamine from the basophils of either donor. On the basis of previous work, serum histamine-releasing activity can be taken to indicate the presence of functional autoantibodies.17 Journal of Allergy and Clinical Immunology 1999 103, 484-493DOI: (10.1016/S0091-6749(99)70475-6) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 2 EG2+ cells, eosinophils detected by H&E staining, NE+ cells, and CD3+ cells in biopsy specimens from the skin of healthy control subjects (n = 12), uninvolved skin from patients with CIU (n = 22), skin from wheals of less than 4 hours’ duration (n = 22), and skin from wheals of greater than 12 hours’ duration (n = 13, except CD3 in which n = 12). The median, 25th and 75th percentiles, and minimum and maximum cell counts are shown. The Mann-Whitney U test was used to compare cell counts in biopsy specimens from the skin of healthy control subjects and uninvolved skin from patients with CIU. The Wilcoxon signed-rank test was used to compare paired cell counts from uninvolved skin and wheals of less than 4 or greater than 12 hours’ duration. Journal of Allergy and Clinical Immunology 1999 103, 484-493DOI: (10.1016/S0091-6749(99)70475-6) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 3 Number of EG2+ cells, eosinophils detected by H&E staining, NE+ cells, and CD3+ cells in biopsy specimens from patients with (n = 10) and without (n = 12) autoantibodies. Biopsy specimens were taken from uninvolved skin and from wheals of less than 4 hours’ duration in all patients and from wheals of greater than 12 hours’ duration in 7 patients with autoantibodies (except CD3 in which n = 6) and 6 patients without autoantibodies. Journal of Allergy and Clinical Immunology 1999 103, 484-493DOI: (10.1016/S0091-6749(99)70475-6) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 4 EG2+ cells in biopsy specimens from patients with spontaneous wheals from DPU (n = 10) and those with weakly positive or negative test results for mild or absent DPU (n = 11). Biopsy specimens were taken from uninvolved skin and from wheals of less than 4 hours’ duration in all patients and from wheals of greater than 12 hours’ duration in 6 patients in each group. The median, 25th and 75th percentiles, and minimum and maximum cell counts are shown. Journal of Allergy and Clinical Immunology 1999 103, 484-493DOI: (10.1016/S0091-6749(99)70475-6) Copyright © 1999 Mosby, Inc. Terms and Conditions