Classification of anti-FcϵRI and anti-IgE autoantibodies in chronic idiopathic urticaria and correlation with disease severity Ruth A. Sabroe, MDa, Edda.

Slides:

Advertisements

Similar presentations

Anaphylaxis induced by horsefly bites: Identification of a 69 kd IgE-binding salivary gland protein from Chrysops spp. (Diptera Tabanidae) by western.

Advertisements

Identification of the allergenic components of kiwi fruit and evaluation of their cross- reactivity with timothy and birch pollens Elide A. Pastorello,

Recombinant allergen fragments as candidate preparations for allergen immunotherapy Thomas Zeiler, MDa, Antti Taivainen, MD, PhDb, Marja Rytkönen, PhDa,

In vitro lymphocyte proliferation with milk and a casein–whey protein hydrolyzed formula in children with cow's milk allergy Philippe A. Eigenmann, MD,

False-positive skin prick test responses to commercially available dog dander extracts caused by contamination with house dust mite (Dermatophagoides.

In vivo sensitization to purified Hevea brasiliensis proteins in health care workers sensitized to natural rubber latex David I. Bernstein, MDa, Raymond.

Kiwi fruit allergy: A new birch pollen–associated food allergy

Evaluation and treatment of allergic fungal sinusitis. II

Assessment of skin prick test and serum specific IgE detection in the diagnosis of Cupressaceae pollinosis Adriano Mari, MDa,b, Gabriella Di Felice,

Different expression of cytokine and membrane molecules by circulating lymphocytes on acute mental stress in patients with atopic dermatitis in comparison.

A clinical analysis of gelatin allergy and determination of its causal relationship to the previous administration of gelatin-containing acellular pertussis.

Identification of common allergenic structures in mugwort and ragweed pollen Reinhold Hirschwehr, MDa, Claudia Heppner, MSca, Susanne Spitzauer, MDb,

Terumi Midoro-Horiuti, MD, PhDa, Randall M

Kiwi fruit allergy: A new birch pollen–associated food allergy

Identification of allergens in fruits and vegetables: IgE cross-reactivities with the important birch pollen allergens Bet v 1 and Bet v 2 (birch profilin)

Predominance of type 2 cytokine–producing CD4+ and CD8+ cells in patients with atopic dermatitis Masatoshi Nakazawa, DVMa, Nakako Sugi, MDb, Hiroshi.

Evaluation and treatment of allergic fungal sinusitis. II

In vitro lymphocyte proliferation with milk and a casein–whey protein hydrolyzed formula in children with cow's milk allergy Philippe A. Eigenmann, MD,

Asthma and increased bronchial responsiveness in elite athletes: Atopy and sport event as risk factors Ilkka J. Helenius, MDa, Heikki O. Tikkanen, MDb,

Comparison of once-daily ebastine 20 mg, ebastine 10 mg, loratadine 10 mg, and placebo in the treatment of seasonal allergic rhinitis Paul H. Ratner,

Immediate-type hypersensitivity reaction to ingestion of mycoprotein (Quorn) in a patient allergic to molds caused by acidic ribosomal protein P2 Michael.

Recombinant allergen fragments as candidate preparations for allergen immunotherapy Thomas Zeiler, MDa, Antti Taivainen, MD, PhDb, Marja Rytkönen, PhDa,

Fuad M. Baroody, MD, Se-Hoon Suh, MD, Robert M. Naclerio, MD

Effects of cooking methods on peanut allergenicity

Allergy to eggs from duck and goose without sensitization to hen egg proteins Belén Añíbarro, MD, F.Javier Seoane, MD, Concepción Vila, MD, Manuel Lombardero,

Low-dose levalbuterol in children with asthma: Safety and efficacy in comparison with placebo and racemic albuterol Henry Milgrom, MDa, David P. Skoner,

Serum levels of eosinophil cationic protein in allergic diseases and natural allergen exposure Margherita Tomassini, MDa, Laura Magrini, MDa, Guido De.

Paul Van Durme, MDa, Jan L. Ceuppens, MD, PhDa,b, Pascal Cadot, PhDb

Anaphylactic reaction to local administration of rifamycin SV

Allergic rhinoconjunctivitis caused by Harmonia axyridis (Asian lady beetle, Japanese lady beetle, or lady bug) John A. Yarbrough, MDa, Jack L. Armstrong,

Increased sensitivity to bradykinin among African Americans

Suppression of the basophil response to allergen during treatment with omalizumab is dependent on 2 competing factors Donald W. MacGlashan, MD, PhD,

Robert A. Wood, MD, Wanda Phipatanakul, MD, Robert G

Physician-targeted program on inhaled therapy for childhood asthma

Fluticasone propionate aqueous nasal spray reduces inflammatory cells in unchallenged allergic nasal mucosa: Effects of single allergen challenge Adriaan.

Cross-reactivity between Cupressus arizonica and Cupressus sempervirens pollen extracts Bianca Barletta, BSc, Claudia Afferni, BSc, Raffaella Tinghino,

IgE autoantibodies monitored in a patient with atopic dermatitis under cyclosporin A treatment reflect tissue damage Tamar Kinaciyan, MD a*, Susanne.

Barbara Foster, MSa, Lawrence B

Possible dual role of anti-idiotypic antibodies in combined passive and active immunotherapy in honeybee sting allergy Yvan Boutin, PhDa, Marie Jobin,

IgE in unselected like-sexed monozygotic and dizygotic twins at birth and at 6 to 9 years of age: High but dissimilar genetic influence on IgE levels

Molecular virology and immunology of HIV infection

Cutaneous inflammatory cell infiltrate in chronic idiopathic urticaria: Comparison of patients with and without anti-FcϵRI or anti-IgE autoantibodies

Rachel L. Miller, MDa, Thomas M

Serum autoreactivity predicts time to response to omalizumab therapy in chronic spontaneous urticaria Janine Gericke, PhD, Martin Metz, MD, Tatevik Ohanyan,

Increased expression of the CD80 accessory molecule by alveolar macrophages in asthmatic subjects and its functional involvement in allergen presentation.

No correlation between wine intolerance and histamine content of wine

Fatal outcome of anaphylaxis to camomile-containing enema during labor: A case study Erika Jensen-Jarolim, MDa, Norbert Reider, MDb, Ruth Fritsch, MDa,

Basophil and eosinophil accumulation and mast cell degranulation in the nasal mucosa of patients with hay fever after local allergen provocation Alex.

Human monoclonal or polyclonal antibodies recognize predominantly discontinuous epitopes on bee venom phospholipase A2 Theres Schneidera, Alois B. Lang,

Association of humoral immunodeficiency, cleidocranial dysplasia, and von Willebrand’s disease in a family cluster Pramod S. Kelkar, MD, Rosa M. Ten,

Case report: Streptomycin-induced anaphylactic shock during oocyte retrieval procedures for in vitro fertilization Motoyasu Iikura, MD, PhDa, Masao Yamaguchi,

TH1/TH2 cytokines and inflammatory cells in skin biopsy specimens from patients with chronic idiopathic urticaria: Comparison with the allergen-induced.

The role and remediation of animal allergens in allergic diseases

G. Weyman Price, MDa, b, Angela D. Hogan, MDc, A. Holly Farris, BAa, A

The potential clinical utility of serum α-protryptase levels

Chemical constituents of diesel exhaust particles induce IL-4 production and histamine release by human basophils Gilles Devouassoux, MDa, Andrew Saxon,

Studies on the relationship between the level of specific IgE antibodies and the clinical expression of allergy: I. Definition of levels distinguishing.

Rame A. Taha, MDa, Eleanor M. Minshall, PhDa, Donald Y. M

Local expression of ϵ germline gene transcripts and RNA for the ϵ heavy chain of IgE in the bronchial mucosa in atopic and nonatopic asthma Sun Ying,

A molecular model of type I allergy: Identification and characterization of a nonanaphylactic anti-human IgE antibody fragment that blocks the IgE-FcϵRI.

Clinical and immunologic variables in skin of patients with atopic eczema and either positive or negative atopy patch test reactions Elisabeth G. Langeveld-Wildschut,

Evidence for aberrant regulation of the p21Ras pathway in PBMCs of patients with chronic idiopathic urticaria Ronit Confino-Cohen, MD, Dorit Aharoni,

False-positive skin prick test responses to commercially available dog dander extracts caused by contamination with house dust mite (Dermatophagoides.

Advances in allergic skin diseases

Allergenicity of goat’s milk in children with cow’s milk allergy

In vivo sensitization to purified Hevea brasiliensis proteins in health care workers sensitized to natural rubber latex David I. Bernstein, MDa, Raymond.

IgE reactivity to α1 and α2 chains of bovine type 1 collagen in children with bovine gelatin allergy Masahiro Sakaguchi, PhDa, Hisae Hori, PhDc, Shunji.

Philippe A. Eigenmann, MD,a, A. Wesley Burks, MD,b, Gary A

The effects of gastric digestion on codfish allergenicity

Bronchial allergen challenge with isolated major allergens of Dermatophagoides pteronyssinus: The role of patient characteristics in the early asthmatic.

Presentation transcript:

Classification of anti-FcϵRI and anti-IgE autoantibodies in chronic idiopathic urticaria and correlation with disease severity Ruth A. Sabroe, MDa, Edda Fiebiger, PhDb, David M. Francis, BSca, Dieter Maurer, MDb, Paul T. Seed, MSc, C Statc, Clive E.H. Grattan, MA, MDd, Anne Kobza Black, MDa, Georg Stingl, MDb, Malcolm W. Greaves, MD, PhDa, Robert M. Barr, PhDa Journal of Allergy and Clinical Immunology Volume 110, Issue 3, Pages 492-499 (September 2002) DOI: 10.1067/mai.2002.126782 Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 1 Patients can be subdivided into 5 categories depending on histamine release assays and Western blot analysis. Western blot analysis score (0-3) for anti-FcϵRI autoantibodies in sera from 78 patients with CIU is plotted against histamine release from IgE-stripped basophils (A) , IgE-sensitized basophils (B) , and mast cells in skin slices (C) . Histamine release was considered positive if 5% or more of the total histamine was released, as indicated by the dashed line . Filled circles, IgE-stripped basophils (FcϵRI histamine release positive); filled inverted triangles, IgE-sensitized basophils (anti-IgE); open squares, mast cell-specific histamine release; open triangles, no histamine-releasing activity, positive Western blot result (anti-FcϵRI histamine release negative); open circles, no histamine-releasing activity, negative Western blot result. Journal of Allergy and Clinical Immunology 2002 110, 492-499DOI: (10.1067/mai.2002.126782) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 2 Identification of patients with predominant anti-IgE autoantibodies. Variation in the log ratio of histamine release (HR) from IgE-stripped and IgE-sensitized basophils is plotted for 27 patients with CIU with serum histamine-releasing activity. The mean log ratio (±4 SDs) for mAb 22E7 used as a control secretagogue, which is not competitive with IgE for binding to FcϵRI, are shown by solid lines (mean) and dashed lines (±4 SDs; n = 4 experiments for IgE-stripped and IgE-sensitized basophils). Histamine release with mAb 22E7 from IgE-stripped and IgE-sensitized basophils was 23.1% ± 3.4% and 26.1% ± 3.0% (mean ± SD), respectively. As in Fig 1, filled circles, IgE-stripped basophils (FcϵRI histamine release positive); filled inverted triangles, IgE-sensitized basophils (anti-IgE). Journal of Allergy and Clinical Immunology 2002 110, 492-499DOI: (10.1067/mai.2002.126782) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 3 Relationship between CIU subset and the severity of clinical features. The CIU subset is plotted against urticaria activity score (A) , wheal distribution score (B) , number of associated systemic symptoms (C) , and worst episodes of itching (D) . Statistical analysis of data is given in Table IV. As in Fig 1, filled circles, IgE-stripped basophils (FcϵRI histamine release positive); filled inverted triangles, IgE-sensitized basophils (anti-IgE); open squares, mast cell-specific histamine release; open triangles, no histamine-releasing activity, positive Western blot result (anti-FcϵRI histamine release negative); open circles, no histamine-releasing activity, negative Western blot result. Journal of Allergy and Clinical Immunology 2002 110, 492-499DOI: (10.1067/mai.2002.126782) Copyright © 2002 Mosby, Inc. Terms and Conditions