Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen.

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Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen breakdown Changhai Ding, M.D., Patrick Garnero, Ph.D., Flavia Cicuttini, Ph.D., Fiona Scott, M.B.B.S., Helen Cooley, M.D., Graeme Jones, M.D. Osteoarthritis and Cartilage Volume 13, Issue 3, Pages 198-205 (March 2005) DOI: 10.1016/j.joca.2004.11.007 Copyright © 2004 OsteoArthritis Research Society International Terms and Conditions

Fig. 1 Sagittal T1-weighted fat saturated 3D MRI images shows: (A) Normal lateral tibial, lateral femoral and patellar cartilage (grade 0). (B) Slight cartilage defects at lateral tibial and patellar site (grade 1) but moderate cartilage defects at lateral femoral site (grade 2). (C) Normal cartilage at patellar site (grade 0) but severe cartilage defects at lateral tibial and femoral sites (grade 3). (D) Severe cartilage defects at medial tibial (grade 4) and femoral (grade 3) sites. Osteoarthritis and Cartilage 2005 13, 198-205DOI: (10.1016/j.joca.2004.11.007) Copyright © 2004 OsteoArthritis Research Society International Terms and Conditions

Fig. 2 Correlation between knee cartilage defects and U-CTX-II. There were significant positive associations between CTX-II and knee cartilage defect severity in all compartments in total sample and women, but not men. T: total sample; F: females; M: males. Osteoarthritis and Cartilage 2005 13, 198-205DOI: (10.1016/j.joca.2004.11.007) Copyright © 2004 OsteoArthritis Research Society International Terms and Conditions