Kreton Mavromatis, MD, Vinod H

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Transcatheter Aortic Valve Replacement in Patients With Aortic Stenosis and Mitral Regurgitation Kreton Mavromatis, MD, Vinod H. Thourani, MD, Amanda Stebbins, MS, Sreekanth Vemulapalli, MD, Chandan Devireddy, MD, Robert A. Guyton, MD, Roland Matsouaka, PhD, Nima Ghasemzadeh, MD, Peter C. Block, MD, Bradley G. Leshnower, MD, James P. Stewart, MD, John S. Rumsfeld, MD, PhD, Stamatios Lerakis, MD, Vasilis Babaliaros, MD The Annals of Thoracic Surgery Volume 104, Issue 6, Pages 1977-1985 (December 2017) DOI: 10.1016/j.athoracsur.2017.05.065 Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Clinical events after TAVR. (A) All cause mortality. (B) Heart failure rehospitalization. (C) Mortality or heart failure rehospitalization. (MR = mitral regurgitation.) The Annals of Thoracic Surgery 2017 104, 1977-1985DOI: (10.1016/j.athoracsur.2017.05.065) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Hazard ratio incurred by mitral regurgitation on clinical outcomes. Adjusted HRs derived from Cox regression analysis. Effect estimates (95% CI) compared with No MR. (A) 30-day mortality. (B) 30-day mortality or heart failure rehospitalization. (C) 1-year mortality. (D) 1-year mortality or heart failure rehospitalization. (Mod = moderate.) The Annals of Thoracic Surgery 2017 104, 1977-1985DOI: (10.1016/j.athoracsur.2017.05.065) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Mitral regurgitation in patients undergoing transcatheter aortic valve replacement. (Mod = moderate; MR = mitral regurgitation; TAVR = transcatheter aortic valve replacement.) The Annals of Thoracic Surgery 2017 104, 1977-1985DOI: (10.1016/j.athoracsur.2017.05.065) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Mortality after TAVR: patients with improved MR (>1 grade) versus no improvement. (A) Moderate and severe MR. (B) Moderate MR. (C) Severe MR. (MR = mitral regurgitation; TAVR = transcatheter aortic valve replacement.) The Annals of Thoracic Surgery 2017 104, 1977-1985DOI: (10.1016/j.athoracsur.2017.05.065) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 Heart failure rehospitalization after TAVR: patients with improved MR (>1 grade) versus no improvement. (A) Moderate and severe MR. (B) Moderate MR. (C) Severe MR. (HF = heart failure; MR = mitral regurgitation; Rehosp = rehospitalization; TAVR = transcatheter aortic valve replacement.) The Annals of Thoracic Surgery 2017 104, 1977-1985DOI: (10.1016/j.athoracsur.2017.05.065) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions