D.J. Pawson, M. Glanzmann, H. Bangar, K. Atal, R. Müller, K.S. Stok

Slides:

Advertisements

Similar presentations

Validity and responsiveness of a new measure of knee osteophytes for osteoarthritis studies: data from the osteoarthritis initiative M. Hakky, M. Jarraya,

Advertisements

Full-thickness cartilage defects repaired by human induced pluripotent stem cells (IPSCS)-derived mesenchymal stem cells and plga scaffolds D. Shi, X.

Cartilage Thickness, Denudation and Kl Grade: A Study of Medial Femorotibial Joints in 8,890 Knees from the Osteoarthritis Initiative G. Guillard, G.R.

Long-term periarticular bone adaptation in a feline knee injury model for post-traumatic experimental osteoarthritis S.K. Boyd, Ph.D., R. Müller, Ph.D.,

A. Bhave, M. Mont, M. Chugthai, R. Starr Osteoarthritis and Cartilage

R. Takeuchi, H. Ishikawa, T. Kuniya, A. Nakazawa

K.S. Santangelo Osteoarthritis and Cartilage

S. Gavard Osteoarthritis and Cartilage

Isotropic three-dimensional T2 mapping of knee cartilage with T2-prepared segmented gradient ECHO at 3T R. Colotti, P. Omoumi, R.B. van Heeswijk Osteoarthritis.

Injectable hydrogels for cartilage repair

Statistical evaluation of biomedical studies

Prospective economic evaluation of the costs for medications and nutraceuticals in knee osteoarthritis M. Chung, N. Zhao, J.B. Wong, C. Wang Osteoarthritis.

Bone shape does not cause OA – But OA does change bone shape; a study on data from 4654 knees from the Osteoarthritis Initiative M.A. Bowes, C.B. Wolstenholme,

Does a yoga-strengthening program for women with knee osteoarthritis have an effect on gait patterns? An investigation with principal components analysis

Quantitatively-measured bone marrow lesions in the patellofemoral joint: distribution and association with pain C. Ratzlaff, R. Russell, J. Duryea Osteoarthritis.

Role of endothelin-1 in endochondral ossification and osteoarthritis

Mineralization of meniscal enthesis in osteoarthritic knees

Effect of self assembled peptide-mesenchymal stem cell complex on delaying the progression of osteoarthritis S. Kim, S. Lee, Y. Jung, J. Kim, S. Kim

M. Finnilä, O-M. Aho, V. Tiitu, J. Thevenot, J. Rautiainen, M

G. Venne, S. Pang, Y. Tse, R. Ellis Osteoarthritis and Cartilage

Mechanical response of articular cartilage damaged by macro cracks

Change in bone area does not correlate with cartilage loss over 12 months in individuals with knee OA: Data from the osteoarthritis initiative M.A. Bowes,

Osteoarthritis and Cartilage

Urine metabolomics using liquid chromatography quadrupole time-of-flight mass spectrometry indicates common markers of disease in alkaptonuria and idiopathic.

The differences on extracellular matrix among each portion of meniscus

Prospective changes in cartilage thickness correlate with knee kinematics at peak loading during walking following anterior cruciate ligament reconstruction

Replicability of recommended exercise interventions for knee osteoarthritis: a descriptive systematic review of current clinical guidelines and recommendations

No effect of additional screw fixation of a cementless, all-polyethylene press-fit socket on migration, wear and clinical outcome: a 6.5 years randomized.

Preclinical investigation of the development of osteoarthritis-like degeneration in a rat trauma model using micro-computed tomography T.H. Steiner,

Association of ultrasound-defined structural changes with regional and diffuse knee pain patterns – Oulu Knee Osteoarthritis study J. Podlipská, P. Kaukinen,

Recombinant adeno associated virus mediated cooverexpression of transforming growth factor beta and SOX9 genes enhance the metabolic and chondrogenic.

Spontaneous development of sclerotic changes of subchondral bone and cartilage degradation in endothelin-1 overexpression transgenic mice upon high fat/high.

B. Vafaeian, S. Adeeb, M. El-Rich, J. Jaremko

Assessing the characteristics of human mesenchymal stromal cells derived from bone marrow and umbilical cord following expansion in the quantum® hollow-fibre.

Alterations in in vivo knee cartilage contact mechanics after anterior cruciate ligament reconstruction and correlations to clinical outcomes and regional.

Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilisation of the medial meniscus and increased joint laxity J.P.

Is increased joint loading detrimental to obese patients with knee osteoarthritis? A secondary data analysis from a randomized trial M. Henriksen, D.J.

Y. Levy, A. Hasegawa, S. Patil, M. Lotz, D. D'Lima

Contrast-enhanced computed tomography imaging using a cationic contrast agent correlates with the equilibrium modulus of mouse tibial plateau cartilage

Osteoarthritis and Cartilage

B. C. Roberts, D. Thewlis, L. B. Solomon, G. Mercer, K. J. Reynolds, E

Effects of low level laser therapy: a study of status of cartilage, subchondral bone and gait adaptation in the rat anterior cruciate ligament transection.

Can bone shape predict who will have their knee replaced

Patellofemoral Bone Morphology is Related to Gender But Not Pain: 3D Quantitative Data Analysis From The OAI M.A. Bowes, B.T. Drew, A.C. Redmond, B.

Emerging role of endothelin receptor type B in regulating chondrogenic and hypertrophic changes of human mesenchymal stem cells M. Au, M. Zhu, W.-J.

Z. Huang, T. Stabler, F. Pei, V. Kraus Osteoarthritis and Cartilage

Evidence for bone mineral density and bone resorption in middle and elderly women with knee osteoarthritis in Shanghai: a cross sectional study Q. Xiaofeng

The association between hip bone marrow lesions and bone mineral density: a cross- sectional and longitudinal population-based study H. Ahedi, D. Aitken,

Walking with increased foot progression angle can reduce joint compression in individuals with knee OA K. Manal, T.S. Buchanan Osteoarthritis and Cartilage

Monocyte chemoattractant protein 1 induced chondrocytes degeneration and cartilage degradation in osteoarthritis X. yuankun, K. Yan, W. Bin, L. Jian-Hao

P. Rahnamay Moshtagh, N. M. Korthagen, S. G. Plomp, B. Pouran, A

Multivariate pattern analysis of physical activity and cartilage health: data from the osteoarthritis initiative E. Halilaj, T.J. Hastie, G.E. Gold,

In vivo structural analysis of subchondral trabecular bone in osteoarthritis of the hip using multi-detector row CT K. Chiba, M. Ito, M. Osaki, M. Uetani,

3D modelling of the hip joint from clinical imaging data

Sensitive discrimination metrics of structural deterioration in a preclinical osteoarthritis- like rat trauma model A. Villarreal, K. Atal, T.H. Steiner,

Imaging biomarker with T1 and T2 mappings in osteoarthritis – In vivo human articular cartilage study C. Yan, C. Wong, T. Li, N. Gong, Q. Chan, K. Chiu

Weather, air pollution and rheumatic diseases: a prospective and correlational study of influence of weather and air pollution on the perception of joint.

How does lower leg alignment differ between soccer players, other athletes and non- athletic controls? W. colyn, R. Agricola, N. Arnout, J. Verhaar, J.

CD14 deficiency dampens osteoclastogenesis and alters bone remodeling in a murine model of osteoarthritis C. Zhou, V. Nguyen, R. Smalley, N. Sambamurthy,

A. B. González-Gil, E. Muinos-López, P. Ripalda-Cemboráin, T

K. Sabashi, M. Yamanaka, T. Chiba, M. Samukawa, H. Saitoh, M. Yuri, H

Knee kinematic and kinetic modifications under body weight unloading during overground walking at a constant speed A.G. Fischer, E.M. Debbi, A. Wolf

Amyloid micronetworks for cartilage repair

The Effect of Oral PC-III on Osteoarthritis and Bone Marrow Lesions

Discovery of a small molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying treatment for knee osteoarthritis J.D. Hood, V.

Quadriceps/Hamstrings co-activation during gait in individuals with anterior cruciate ligament reconstruction T. Blackburn, B. Pietrosimone, J. Goodwin,

Comprehensive morphological characterisation of osteoarthritis in a preclinical rabbit trauma model using micro computed tomography K.S. Stok, K. Atal,

A. Carlson, B. Bothner, R. June Osteoarthritis and Cartilage

General Information Osteoarthritis and Cartilage

Long-term effects of vitamin d supplementation and maintaining vitamin d sufficiency on knee osteoarthritis over 5 years B. Antony, S. Zheng, J. Burgess,

Presentation transcript:

Identifying structural cues involved with osteoarthritis disease in human humeral heads D.J. Pawson, M. Glanzmann, H. Bangar, K. Atal, R. Müller, K.S. Stok Osteoarthritis and Cartilage Volume 22, Pages S368-S369 (April 2014) DOI: 10.1016/j.joca.2014.02.682 Copyright © 2014 Terms and Conditions

Figure 1 (a) Osteoporosis-like sample with intact cartilage and complete loss of trabecular structure (indicated by arrow), (b) Sclerotic sample with loss of cartilage covering the bone, osteophyte growth (right arrow), and large bone marrow oedema holes (left arrows). Colour indicates cartilage thickness, where blue is thinnest and red is thickest. Osteoarthritis and Cartilage 2014 22, S368-S369DOI: (10.1016/j.joca.2014.02.682) Copyright © 2014 Terms and Conditions

Figure 2 (a) Plot of cartilage thickness and trabecular thickness, wherein each sample specific correlation yields an inverse relationship in sclerotic samples. Individual correlation coefficients are R = 0.62, 0.87, 0.88, 0.85. 0.60, 0.77, respectively, (b) Plot of denuded surface and bone volume/total volume, indicating, for each sample, greater bone density in regions of lost cartilage coverage. Individual correlation coefficients are R = 0.41, 0.84, 0.74, 0.38, 0.80, 0.41, respectively. The combined correlation coefficients for Cg.Th versus Tb.Th and %DS versus BV/TV, are 0.74 and 0.56, respectively. Osteoarthritis and Cartilage 2014 22, S368-S369DOI: (10.1016/j.joca.2014.02.682) Copyright © 2014 Terms and Conditions