Volume 63, Issue 1, Pages (January 2003)

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Volume 63, Issue 1, Pages 233-239 (January 2003) Familial collapsing glomerulopathy: Clinical, pathological and immunogenetic features M. Carmen Avila-Casado, Gilberto Vargas-Alarcon, Maria E. Soto, Guadalupe Hernandez, Pedro A. Reyes, Jaime Herrera-Acosta Kidney International Volume 63, Issue 1, Pages 233-239 (January 2003) DOI: 10.1046/j.1523-1755.2003.00713.x Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 1 Renal biopsy of patient 1. Glomerulus shows characteristic capillary collapse and prominence of visceral epithelial cells that contain blebs and vacuoles (PAS stain, ×400). Kidney International 2003 63, 233-239DOI: (10.1046/j.1523-1755.2003.00713.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 2 Renal biopsy from patient 2. Periodic acid-Schiff positive hyaline droplets within hypertrophied visceral epithelial cells can be seen (×400). Kidney International 2003 63, 233-239DOI: (10.1046/j.1523-1755.2003.00713.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 3 Renal biopsy from patient 3. Capillary collapse and retraction. Visceral epithelial cells appear prominent and contain vacuoles. A segmental area of sclerosis is also seen (PAS stain, ×400). Kidney International 2003 63, 233-239DOI: (10.1046/j.1523-1755.2003.00713.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 4 Renal biopsy from patient 4 showing capillary collapse and retraction of the glomerular tuft. Visceral epithelial cells appear prominent and contain vacuoles and blebs (×400). Kidney International 2003 63, 233-239DOI: (10.1046/j.1523-1755.2003.00713.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 5 Imunogenetic analysis of eleven members of the family. Siblings III-7, III-8, III-9 and III-11 affected with CG (arrows) and the youngest brother without CG (III-10) share the same MHC haplotype inherited from the mother (A24, B14, DR1, DQA1*0101, DQB1*0501). Patients III-7 and III-8 also have systemic erythematosus-like disease (SLE-like) and they share the A74, B8, DR1, DQA1*0101, DQB 1*0501 haplotype. The individual II-6 (mother's sister) has rheumatoid arthritis (RA). Kidney International 2003 63, 233-239DOI: (10.1046/j.1523-1755.2003.00713.x) Copyright © 2003 International Society of Nephrology Terms and Conditions