Crystal Structure of a SEA Variant in Complex with MHC Class II Reveals the Ability of SEA to Crosslink MHC Molecules Karin Petersson, Marjolein Thunnissen,

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Crystal Structure of a SEA Variant in Complex with MHC Class II Reveals the Ability of SEA to Crosslink MHC Molecules Karin Petersson, Marjolein Thunnissen, Göran Forsberg, Björn Walse Structure Volume 10, Issue 12, Pages 1619-1626 (December 2002) DOI: 10.1016/S0969-2126(02)00895-X

Figure 1 Ribbon Representation of the DR1-SEAD227A Complex with HLA-DR1, in Green, Ha-Peptide, in Red, and SEAD227A, in Yellow Structure 2002 10, 1619-1626DOI: (10.1016/S0969-2126(02)00895-X)

Figure 2 Stereoview of the Cα Chain Representation of the DR1-SEAD227A and DR1-SEB Complexes HLA-DR1 from both complexes has been superimposed. Areas in SEB that are not defined in the crystal structure are not displayed. HLA-DR1, green; antigenic peptide, red; SEAD227A, yellow; SEB, cyan. Structure 2002 10, 1619-1626DOI: (10.1016/S0969-2126(02)00895-X)

Figure 3 Ribbon Representations of the Interfaces between (A) HLA-DR1, in Green, and SEAD227A, in Yellow, and (B) HLA-DR1, in Green, and SEB, in Cyan, as Well as Electrostatic Interaction and Hydrogen Bond Pattern of Selected Residues in the Interface Structure 2002 10, 1619-1626DOI: (10.1016/S0969-2126(02)00895-X)

Figure 4 Structural Overview of Modeled Complexes (A) Model of the quaternary complex, which illustrates SEA (yellow) crosslinking two HLA-DR1 molecules (green) as well as interacting with the T cell receptor (blue). The insertion illustrates the ability of the quaternary complex to create a regular distance between the APC and the T cell. (B) Model of an HLA-DR1 (green) molecule presenting two SEA (yellow) molecules, where the first SEA molecule will be unable to interact with TCR because of the Vα chain of TCR and the second SEA molecule will totally overlap, according to Figure 4A. Structure 2002 10, 1619-1626DOI: (10.1016/S0969-2126(02)00895-X)