The Role of Human Dendritic Cells in HIV-1 Infection Zahra Ahmed, Tatsuyoshi Kawamura, Shinji Shimada, Vincent Piguet  Journal of Investigative Dermatology  Volume 135, Issue 5, Pages 1225-1233 (May 2015) DOI: 10.1038/jid.2014.490 Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Human dendritic cell (DC) subsets and the role in HIV infection. LCs, Langerhans cells; pDCs, plasmacytoid dendritic cells. Journal of Investigative Dermatology 2015 135, 1225-1233DOI: (10.1038/jid.2014.490) Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Infection of dendritic cells (DCs) and restriction steps. HIV-1 binds to CD4 and chemokine receptor CCR5, allowing infection of DCs via fusion with cell membrane. However, there are several restriction factors preventing HIV-1 propagation acting at different stages of the viral life cycle shown in blue. Tripartite motif-5α (TRIM-5α) binds to the viral capsid to help disrupt its disassembly. The counteracting viral factor Gag capsid antigen (Gag-CA) is shown in red. Sterile alpha motif and HD domain 1 (SAMHD1) potently blocks reverse transcription at this post-entry step by reducing dNTPs pool, with the counteracting viral factor protein X (Vpx) shown in red. Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G) incorporates itself into newly made virions and restricts HIV replication potentially via limiting reverse transctiption and by causing hypermutation. The counteracting viral factor is virion infectivity factor (Vif), shown in red. Myxovirus resistance 2 (MX2) offers IFN-α-mediated resistance to multiple HIV strains by blocking the virus at a late post-entry stage, and finally tetherin prevents viral budding and release by tethering the virus at the cell surface. The counteracting viral factor Vpu is shown in red. Journal of Investigative Dermatology 2015 135, 1225-1233DOI: (10.1038/jid.2014.490) Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions