Volume 7, Pages (January 2019)

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Volume 7, Pages 47-54 (January 2019) A Whole-genome Sequencing Analysis of Neisseria gonorrhoeae Isolates in China: An Observational Study Jun-Ping Peng, Yue-Ping Yin, Shao-Chun Chen, Jian Yang, Xiu-Qin Dai, He-Ping Zheng, Wei-Ming Gu, Bang-Yong Zhu, Gang Yong, Na Zhong, Li-Hua Hu, Wen-Ling Cao, Zhong-Jie Zheng, Feng Wang, Qi Zhi, Chi Zhang, Le-Shan Xiu, Bo Liu, Jie Dong, Li-Lian Sun, Ya- Fang Zhu, Xiang-Sheng Chen, Qi Jin EClinicalMedicine Volume 7, Pages 47-54 (January 2019) DOI: 10.1016/j.eclinm.2019.01.010 Copyright © 2019 Terms and Conditions

Fig. 1 Geographic locations of the provinces where the N. gonorrhoeae isolates were collected for the study. The number of isolates from each province is given in parentheses. EClinicalMedicine 2019 7, 47-54DOI: (10.1016/j.eclinm.2019.01.010) Copyright © 2019 Terms and Conditions

Fig. 2 Phylogenetic analysis. Four representative strains of N. meningitidis were included as outgroups. Maximum-likelihood tree of 2512 N. gonorrhoeae isolates based on 69,374 genome-wide SNP sites. Four representative strains of N. meningitidis (Z2491, MC58, FAM18 and 053442)were used as outgroups. Lineage 1 (L1) and 9 sub-lineages of lineage 2 (L2) are marked with background shadows. The proportions of predominate MLST types of each lineage/sub-lineage are highlighted by internal pie charts with size proportional to the total number of isolates. The external color strips range from 1 (inner) to 3 (outer). Strip 1, isolates with predominate MLST types of the current dataset. Strip 2, origin of each strain with color code for countries: deep pink, China; sky blue, USA; light green, UK. Strip 3, distribution of N. gonorrhoeae strains isolated from southeast (orange) and northwest (blue) of China. The scale is in the units of mutations per site. EClinicalMedicine 2019 7, 47-54DOI: (10.1016/j.eclinm.2019.01.010) Copyright © 2019 Terms and Conditions

Fig. 3 Phylogenetic analysis of 635 NG isolates. A degraded maximum-likelihood tree of 635 N. gonorrhoeae strains with available cephalosporin antibiotics susceptibility information. Four reference completes, FA1090, FA19, MS11 and NCCP11945 are also included. Colored dots at the leaves denote cephalosporin antibiotic resistance (red) or sensitive (blue) isolates. The external color strip indicates the sources of each isolates: deep pink, the current study; sky blue, USA cohort; gold, representative strains from WHO; gray, reference genomes. The scale is in the units of mutations per site. EClinicalMedicine 2019 7, 47-54DOI: (10.1016/j.eclinm.2019.01.010) Copyright © 2019 Terms and Conditions