TSG-6 activity as a novel biomarker of progression in knee osteoarthritis  H.-G. Wisniewski, E. Colón, V. Liublinska, R.J. Karia, T.V. Stabler, M. Attur, S.B. Abramson, P.A. Band, V.B. Kraus  Osteoarthritis and Cartilage  Volume 22, Issue 2, Pages 235-241 (February 2014) DOI: 10.1016/j.joca.2013.12.004 Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 TSG-6 activities in synovial fluid by knee OA progression status. Shown is a box plot of TSG-6 activities in four OA outcome categories: NP (N = 60), OST only progressors (OST+/JSN−, N = 49), JSN progressors (OST+/JSN+, N = 12), and TKA progressors (N = 11), as indicated. The boxes indicate 10%, 25%, 75% and 90% quantiles and the median for each outcome group. The line indicates the mean of the whole sample (N = 132, mean = 9.85 u/ml). Osteoarthritis and Cartilage 2014 22, 235-241DOI: (10.1016/j.joca.2013.12.004) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 ROC curve for the TSG-6 activity assay and the outcome TKA vs non-TKA. The area under the curve is 0.90. A TSG-6 cut-off point of 13.3 u/ml, determined by Youden's index, yielded a sensitivity of 0.91 and a specificity of 0.82. Osteoarthritis and Cartilage 2014 22, 235-241DOI: (10.1016/j.joca.2013.12.004) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions