Fig. 5 HDAC inhibition blocks age-dependent diastolic dysfunction.

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Fig. 5 HDAC inhibition blocks age-dependent diastolic dysfunction. HDAC inhibition blocks age-dependent diastolic dysfunction. (A) Study overview. Nine-month-old female 129S6/SvEvTac mice were fed normal chow or chow containing ITF2357 (50 mg/kg) for 11 months. Serial echocardiography was performed at 9, 15, 17, and 20 months. (B) Doppler measurement of mitral inflow velocity (E/A) in aged mice treated with vehicle or HDAC inhibitor. Measurements of septal mitral annulus velocities (E′/A′) (C) and IVRT (D). Mouse numbers for each time point are provided in table S7. Mean systemic blood pressure (MSP) (E) and LV-to-tibia length (F) in 20-month-old mice treated with or without ITF2357. (G to J) Ex vivo mechanics analyses of myofibrils from 20-month-old mice fed normal chow or ITF2357-containing chow. Data are mean + SEM and were compared by Student’s t test. *P < 0.05 versus untreated controls. n = 4 mice per group; 9 to 10 myofibril bundles were analyzed per animal. Mark Y. Jeong et al., Sci Transl Med 2018;10:eaao0144 Published by AAAS