Willard C. Johnson, M. D. , Joanna M. Sentissi, M. D

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Presentation transcript:

Treatment of claudication with pentoxifylline: Are benefits related to improvement in viscosity?  Willard C. Johnson, M.D., Joanna M. Sentissi, M.D., Donna Baldwin, R.N., Janis Hamilton, R.N., Janice Dion, R.N.  Journal of Vascular Surgery  Volume 6, Issue 3, Pages 211-216 (September 1987) DOI: 10.1016/0741-5214(87)90029-2 Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 1 Porous Plug Viscometer. Journal of Vascular Surgery 1987 6, 211-216DOI: (10.1016/0741-5214(87)90029-2) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 2 Correlation of viscosity as determined by the Wells-Brookfield Viscometer and the filtration time of Porous Plug Viscometer. The regression line is y = 0.242 × 1.39. (r = 0.735; p = 0.01.) Journal of Vascular Surgery 1987 6, 211-216DOI: (10.1016/0741-5214(87)90029-2) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 3 Changes in initial claudication distance (A) and absolute claudication distance (B) associated with pentoxifylline therapy. Improvement in viscosity was defined as none when the change was less than 0.25 cp, small if 0.25 to 1.00 cp, mild if 1.01 to 2.00 cp, and moderate if greater than 2.00 cp. Journal of Vascular Surgery 1987 6, 211-216DOI: (10.1016/0741-5214(87)90029-2) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 4 Correlation between improved viscosity and improved absolute claudication distances: dark boxes represent a good correlation; gray boxes a fair correlation; and white boxes a poor correlation. Journal of Vascular Surgery 1987 6, 211-216DOI: (10.1016/0741-5214(87)90029-2) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 5 Correlation between symptomatic improvement and improved absolute claudication distances: dark boxes represent a good correlation; gray boxes a fair correlation; and white boxes a poor correlation. Journal of Vascular Surgery 1987 6, 211-216DOI: (10.1016/0741-5214(87)90029-2) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions