Figure 1 Lesion locations causing cervical dystonia

Slides:

Advertisements

Similar presentations

Figure 3 Anatomical distribution of all implanted electrodes

Advertisements

Figure 1 Experimental workflow and predictive modelling

Unless provided in the caption above, the following copyright applies to the content of this slide: Published by Oxford University Press on behalf of the.

Figure 1 Flowchart of our CIS cohort considering patients (A) and eyes (B) as statistical unit. Unless provided in the caption above, the following copyright.

Figure 1 Data-selection process

Figure 1 Flow diagram detailing the systematic review process.

Figure 1 Flow diagram of the study

Figure 3 Multivariate regression analysis to display the impact of recanalization on the formation of ischaemic brain ... Figure 3 Multivariate regression.

Figure 1 Network topology as a function of dopaminergic state

Figure 1 Increased absolute mean curvature in very premature-born adults. Statistical parametric map of group ... Figure 1 Increased absolute mean curvature.

Figure 1 Mechanism of mortality benefit associated with radial access

(A) mSchober in DESIR; (B) mSchober in SPACE; (C) LSF ...

Figure 1 Three example candidate spike ripple events

Figure 1 DRG neurons from dermatomes with radicular/neuropathic pain show ectopic spontaneous activity and ... Figure 1 DRG neurons from dermatomes with.

(A) The heat map shows an overview ...

Unless provided in the caption above, the following copyright applies to the content of this slide: Published by Oxford University Press on behalf of the.

Figure 1 The Kaplan–Meier curves of time to death post first hospitalization. hosp, hospitalization. Unless provided in the caption above, the following.

Figure 1. Serum ceftazidime concentrations following intravenous administration. Unless provided in the caption above, the following copyright applies.

Figure 1 A dot plot illustrating the correlation between the yearly absolute risk difference for both MACE and major ... Figure 1 A dot plot illustrating.

Fig. 1 CT demonstrating aortic wall thickening with renal artery involvement (short arrow). There is also subtle ... Fig. 1 CT demonstrating aortic wall.

Source: Figure created by the author based on data ...

Figure 1 Tau promotes neuronal hypoactivity, even in the absence of tangles. (A) Schematic of the experimental ... Figure 1 Tau promotes neuronal hypoactivity,

bDMARD: biologic DMARD.

Figure 1 Flortaucipir PET MUBADA/PERSI SUVr at baseline, 9 and 18 months for individual subjects. Each subject is ... Figure 1 Flortaucipir PET MUBADA/PERSI.

Black: diagnosis ... Black: diagnosis from any department; grey: diagnosis at a rheumatology department. Unless provided in the caption above, the following.

Fig. 1 MRI aspect of an osteitis of the left acetabulum at baseline (A), 3 months (B), 1 year (C) and 2 years later, ... Fig. 1 MRI aspect of an osteitis.

(A) Strain elastography of left submandibular gland in a patient with ... (A) Strain elastography of left submandibular gland in a patient with SS. An.

Figure 1 Mean ± standard error proportions of (a) courtship and (b) copulation by female-male type pairing. Error bars ... Figure 1 Mean ± standard error.

Figure 1. Historical dialectic framework to assess transnational advocacy network influence Unless provided in the caption above, the following copyright.

Take home figure The protective role of CNP/NPR-B/NPRC.

A. PMPs; B. endotheliocyte-derived MPs; C. leukocyte-derived MPs

Fig. 1. A flowchart of cohort participants screened, enrolled and followed-up between 1 July 2015 and 31 May Fig. 1. A flowchart of cohort participants.

Fig. 1 Subacute cutaneous lupus erythematous at the lower limbs

Fig. 1 Flow chart of included patients for analyses

Fig. 1 Flow chart for selection of study subjects

Figure 1 Overview of the image acquisition and analysis steps.

Figure 1 Schematic of the sequential learning task with examples of conflict and uncertainty trials and HDDM. (A) A ... Figure 1 Schematic of the sequential.

Increased ... Increased brain connectivity between the SMN and left insula (A), DMN and right middle frontal gyrus (B) and DAN and bilateral medial prefrontal.

Prevalence and distribution of ...

Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology.

Figure 1. Flow diagram for selection of articles for systematic review. Unless provided in the caption above, the following copyright applies to the content.

Figure 1. Time–kill studies for selected isolates (each line represents the average of duplicate studies). AMP, ... Figure 1. Time–kill studies for selected.

Figure 1. Percentage of Pacific and European children completing all components of B4SC in 2013 and 2015 Figure 1. Percentage of Pacific and European.

Figure 1 Global neuroanatomical correlates of gf and gc

Figure 1. Trunk and leg fat over study period. LS, log transformed.

Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology.

Figure 1 Summary of patient-level SC-FC analysis pipeline

Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology.

Fig. 1 Kaplan-Meier plot presenting no difference in progression to RA in patients with clinically suspect ... Fig. 1 Kaplan-Meier plot presenting no difference.

Figure 1. Oncoprint of selected pathogenic alterations detected in ctDNA. Unless provided in the caption above, the following copyright applies to the.

Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology.

Unless provided in the caption above, the following copyright applies to the content of this slide: Published by Oxford University Press on behalf of the.

Figure 1 Patient selection

Fig. 1 A network representation of top 100 co-occurring terms

Fig. 1 Statistics of the main characters’ dialogues.

Figure 1 Patient selection.

Fig. 1 Query formulation process in CLIR

Figure 1 Grant agencies and charitable foundations supporting Plan S.

Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology.

Fig. 1 Schematic subcategorization of AAV in three clinically relevant disease categories defined by clinical ... Fig. 1 Schematic subcategorization of.

Figure 1 NMF in ADD patients and classification of prodromal Alzheimer’s disease participants. Grey matter ... Figure 1 NMF in ADD patients and classification.

Fig. 2. Default mode network (DMN) patterns in each of the 3 groups and longitudinal changes after treatment. (A–C) ... Fig. 2. Default mode network (DMN)

Figure 1 Strategies for reconciling protection and participation.

Figure 1: Trade shares of South Korea's major trading partners (% of South Korea's total trade in goods) Figure 1: Trade shares of South Korea's major.

Figure 1 Excitability of primary motor cortex

Figure 1 ABCDE of primary prevention.2

Figure 1. Forest plot of lung cancer mortality in LDCT trials.

Figure 1. PRISMA-style literature-search diagram: schematic outlining structured literature search completed on August ... Figure 1. PRISMA-style literature-search.

Figure 1. Evolutionary process of a policy field.

Table 2. Mean noise level results for hand dryers in dBA

Presentation transcript:

Figure 1 Lesion locations causing cervical dystonia Figure 1 Lesion locations causing cervical dystonia. A systematic literature search identified 25 cases of cervical ... Figure 1 Lesion locations causing cervical dystonia. A systematic literature search identified 25 cases of cervical dystonia with an identifiable lesion location that could be traced onto a standard brain atlas. Case numbers correspond to those in Table 1 and Supplementary Table 1, which provides additional clinical details of cases listed in Table 1. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) (2019). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Brain, awz112, https://doi.org/10.1093/brain/awz112 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 2 Lesion network mapping technique Figure 2 Lesion network mapping technique. In step one, lesions causing cervical dystonia were traced onto a standard ... Figure 2 Lesion network mapping technique. In step one, lesions causing cervical dystonia were traced onto a standard atlas. In step two, connectivity between each lesion location and the rest of the brain was computed using a normative dataset of resting state functional connectivity scans from 1000 healthy individuals, and a standard seed-based approach. In step three, functional connectivity maps were thresholded, binarized (functionally connected or not), and overlapped to identify voxels connected to the greatest number of lesion locations. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) (2019). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Brain, awz112, https://doi.org/10.1093/brain/awz112 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 3 Lesion network mapping of cervical dystonia Figure 3 Lesion network mapping of cervical dystonia. (A) Regions positively correlated (orange/yellow) or negatively ... Figure 3 Lesion network mapping of cervical dystonia. (A) Regions positively correlated (orange/yellow) or negatively correlated (blue/green) to lesion locations causing cervical dystonia (thresholded at 90% or 23/25 cases). From left to right: thalamus (z = 10); globus pallidus (z = −2); midbrain (z = −13); cerebellum (z = −32), and somatosensory cortex (projected onto the brain surface). (B) Regions that are both sensitive and specific to lesions causing cervical dystonia, with significantly greater (positive or negative) functional connectivity to lesion locations causing cervical dystonia compared to control lesion locations (conjunction across four separate specificity analyses). Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) (2019). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Brain, awz112, https://doi.org/10.1093/brain/awz112 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 4 Lesions causing cervical dystonia are part of a commonly connected brain network. The combination of positive ... Figure 4 Lesions causing cervical dystonia are part of a commonly connected brain network. The combination of positive connectivity to our cerebellum region of interest and negative connectivity to our somatosensory region of interest defines a network of regions (blue) that encompasses 24 of 25 lesion locations causing cervical dystonia (red). Case 8 lesion location falls immediately adjacent to this network. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) (2019). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Brain, awz112, https://doi.org/10.1093/brain/awz112 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 5 Relevance to idiopathic cervical dystonia Figure 5 Relevance to idiopathic cervical dystonia. Connectivity with our lesion-derived cerebellar region of interest ... Figure 5 Relevance to idiopathic cervical dystonia. Connectivity with our lesion-derived cerebellar region of interest (A, red) and somatosensory region of interest (B, blue) is abnormal in patients with idiopathic cervical dystonia. Patients with idiopathic cervical dystonia had a loss of negative functional connectivity from our cerebellar region of interest to the right sensorimotor cortex (z = 38) (orange/yellow) (A). Patients with idiopathic cervical dystonia also had loss of negative connectivity from our somatosensory region of interest to regions in the thalamus/basal ganglia and anterior cingulate (z = 12) (orange/yellow), and loss of positive connectivity to the sensorimotor and occipital cortex (z = 27) (blue/green) (B). All images were corrected with threshold-free cluster enhancement P<sub>FWE</sub> < 0.05. Corresponding average (SEM) Fischer z transformed correlation coefficients (Fz) are shown in box and whisker plots. Middle line within plot represents median, and cross shows mean. CD = idiopathic cervical dystonia patients; HV = healthy volunteers. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) (2019). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Brain, awz112, https://doi.org/10.1093/brain/awz112 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 6 Relevance to deep brain stimulation Figure 6 Relevance to deep brain stimulation. Lesions causing cervical dystonia are negatively connected to the ... Figure 6 Relevance to deep brain stimulation. Lesions causing cervical dystonia are negatively connected to the somatosensory cortex and positively to the cerebellum (A). Globus pallidus interna DBS locations associated with good clinical response in cervical dystonia (B) and all dystonia patients (C) also show negative functional connectivity to the somatosensory cortex and positive functional connectivity to the cerebellum. Voxels associated with good response also show similar connectivity profile when controlling for voxels associated with poor response (D). Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) (2019). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Brain, awz112, https://doi.org/10.1093/brain/awz112 The content of this slide may be subject to copyright: please see the slide notes for details.