The Fanconi Anemia Group E Gene, FANCE, Maps to Chromosome 6p

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The Fanconi Anemia Group E Gene, FANCE, Maps to Chromosome 6p Quinten Waisfisz, Cigdem Altay, Peter A. Leegwater, Johan P. de Winter, Kenshi Komatsu, Gareth R. Evans, Rolf-Dieter Wegner, André Reis, Hans Joenje, Fré Arwert, Christopher G. Mathew, Jan C. Pronk, Kathrin Saar, Neil V. Morgan, Martin Digweed The American Journal of Human Genetics Volume 64, Issue 5, Pages 1400-1405 (May 1999) DOI: 10.1086/302385 Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 1 Homozygosity mapping of microsatellite markers spaced at 11-cM intervals in FA family 1. Each box represents a microsatellite marker located on the 22 autosomes; 274 markers were analyzed. Solid boxes indicate markers that were informative and homozygous in the affected child EUFA130 only; hatched boxes indicate markers that were homozygous in EUFA130 but not fully informative; open boxes indicate markers that were heterozygous in EUFA130; and missing boxes indicate further markers of the MDC-Généthon panel that were not analyzed. The American Journal of Human Genetics 1999 64, 1400-1405DOI: (10.1086/302385) Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 2 Most likely haplotypes for microsatellite markers on chromosome 6p. Family 1, with complementation group E reference patient EUFA130, is consanguineous; the parents are first cousins. Family 2 was assigned in this report to complementation group E. Family 3 is consanguineous and was assigned in this report to complementation group E; the parents are second cousins. Symbols for affected individuals are solid. The American Journal of Human Genetics 1999 64, 1400-1405DOI: (10.1086/302385) Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 3 Multipoint analysis of chromosome 6 markers in FA-E families. The American Journal of Human Genetics 1999 64, 1400-1405DOI: (10.1086/302385) Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 4 Map of microsatellite markers on chromosome 6p and the FANCE gene. Genetic distances are indicated in centimorgans (cM). Physical locations of makers are taken from the consensus map of chromosome 6p (Genome Data Base). The American Journal of Human Genetics 1999 64, 1400-1405DOI: (10.1086/302385) Copyright © 1999 The American Society of Human Genetics Terms and Conditions