Volume 134, Issue 1, Pages 259-267 (January 2008) Human Parathyroid Hormone 1–34 Prevents Bone Loss in Experimental Biliary Cirrhosis in Rats  Rivka Dresner–Pollak, Yankel Gabet, Arza Steimatzky, Gilad Hamdani, Itai Bab, Zvi Ackerman, Miron Weinreb  Gastroenterology  Volume 134, Issue 1, Pages 259-267 (January 2008) DOI: 10.1053/j.gastro.2007.10.025 Copyright © 2008 AGA Institute Terms and Conditions

Figure 1 hPTH 1–34 prevents femoral and tibial bone mineral density (BMD) loss in male bile duct-ligated (BDL) rats. Femoral (A) and tibial (B) BMD in sham-operated (SO) rats, BDL rats, and BDL rats treated for 4 weeks with human parathyroid hormone (hPTH 1–34) at 40 μg/kg per day or 80 μg/kg per day. Data are mean ± SE obtained in 8 rats per group. *aDifferent from BDL rats, P < .05; *bdifferent from BDL+hPTH 1–34 80 μg/kg per day rats, P < .05. Gastroenterology 2008 134, 259-267DOI: (10.1053/j.gastro.2007.10.025) Copyright © 2008 AGA Institute Terms and Conditions

Figure 2 Three-dimensional μCT images of distal femoral metaphyseal trabecular bone obtained from animals with median trabecular bone density values. (A) Sham-operated rat. (B) Bile duct-ligated (BDL) rat. (C) BDL rat treated with hPTH 1–34 at 40 μg/kg per day. (D) BDL rat treated with hPTH 1–34 at 80 μg/kg per day. Gastroenterology 2008 134, 259-267DOI: (10.1053/j.gastro.2007.10.025) Copyright © 2008 AGA Institute Terms and Conditions

Figure 3 Trabecular bone mass and architecture parameters determined by μCT in the distal femoral metaphysis of sham-operated (SO) rats, bile duct-ligated (BDL) rats, and BDL rats treated for 4 weeks with hPTH 1–34 at 40 μg/kg per day or 80 μg/kg per day. (A) Trabecular bone volume. (B) Trabecular thickness. (C) Trabecular number. (D) Trabecular spacing. Data are mean ± SE obtained in 8 rats per group. *Different from BDL rats, P < .05; **different from BDL rats, P < .01. Gastroenterology 2008 134, 259-267DOI: (10.1053/j.gastro.2007.10.025) Copyright © 2008 AGA Institute Terms and Conditions