T.S. Hahm, H.J. Ahn, S. Ryu, M.S. Gwak, S.J. Choi, J.K. Kim, J.M. Yu

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Combined carbamazepine and pregabalin therapy in a rat model of neuropathic pain T.S. Hahm, H.J. Ahn, S. Ryu, M.S. Gwak, S.J. Choi, J.K. Kim, J.M. Yu British Journal of Anaesthesia Volume 109, Issue 6, Pages 968-974 (December 2012) DOI: 10.1093/bja/aes306 Copyright © 2012 The Author(s) Terms and Conditions

Fig 1 Dose–effect curve for anti-allodynic effects. British Journal of Anaesthesia 2012 109, 968-974DOI: (10.1093/bja/aes306) Copyright © 2012 The Author(s) Terms and Conditions

Fig 2 Isobologram. A significant difference (P<0.05; t-test) was observed between additive ED75 and experimental ED75 for the drug mixture, indicating a synergistic interaction. The line connecting ED values is the theoretical additive line, that is, points on this line are the theoretical additive value for ED50 or ED75. Units are in milligrams. British Journal of Anaesthesia 2012 109, 968-974DOI: (10.1093/bja/aes306) Copyright © 2012 The Author(s) Terms and Conditions

Fig 3 c-Fos IHC. Expressions of nucleus c-Fos were higher in the control group than in the treatment groups. No differences were observed between the treatment groups. Nuclear staining of rat spinal cord laminae I and II of the left dorsal horn of L5. Twenty-five micrometre cross-section of the spinal cord, 319×319 μm2 grid at ×20 (original magnification). Nuclei stained by DAPI are blue; c-Fos is stained green and nuclear c-Fos stained cyan. The white dotted line is a dividing line between laminae I and II. British Journal of Anaesthesia 2012 109, 968-974DOI: (10.1093/bja/aes306) Copyright © 2012 The Author(s) Terms and Conditions