H. Matsumoto, I. Yataba, N. Otsuka, Y. Hoshino 

Slides:



Advertisements
Similar presentations
Anatomical alignment, but not goniometry, predicts femorotibial cartilage loss as well as mechanical alignment  R. Moyer, W. Wirth, F. Eckstein  Osteoarthritis.
Advertisements

Effects of exercise and weight loss on interstitial matrix turnover and tissue inflammation biomarkers in adults with knee osteoarthritis: the intensive.
Short-term placebo response in trials of patients with symptomatic osteoarthritis: differences between hip and knee  S. Reiter-Niesert, M. Boers, J. Detert 
Dr L. S. Kim, N. D. , Dr L. J. Axelrod, N. D. , Dr P. Howard, M. D
A. Bhave, M. Mont, M. Chugthai, R. Starr  Osteoarthritis and Cartilage 
R. Takeuchi, H. Ishikawa, T. Kuniya, A. Nakazawa 
S. Gavard  Osteoarthritis and Cartilage 
Isotropic three-dimensional T2 mapping of knee cartilage with T2-prepared segmented gradient ECHO at 3T  R. Colotti, P. Omoumi, R.B. van Heeswijk  Osteoarthritis.
Knee joint space width progression: results of a 3
Prospective economic evaluation of the costs for medications and nutraceuticals in knee osteoarthritis  M. Chung, N. Zhao, J.B. Wong, C. Wang  Osteoarthritis.
Bone shape does not cause OA – But OA does change bone shape; a study on data from 4654 knees from the Osteoarthritis Initiative  M.A. Bowes, C.B. Wolstenholme,
Does a yoga-strengthening program for women with knee osteoarthritis have an effect on gait patterns? An investigation with principal components analysis 
Biochemical markers of synovial inflammation – Surrogate markers of synovitis on magnetic resonance imaging? – Data from the osteoarthritis initiative 
Role of endothelin-1 in endochondral ossification and osteoarthritis
W. Hitzl, M. Sattler, F. Eckstein, S. Cotofana 
Automatic cartilage segmentation and measurement for diagnosis of OA using 3D box and Gaussian filters  X. Cui, S. Li, M. Yu, H. Kim, K.-S. Kwack, B.-H.
Mineralization of meniscal enthesis in osteoarthritic knees
Effect of self assembled peptide-mesenchymal stem cell complex on delaying the progression of osteoarthritis  S. Kim, S. Lee, Y. Jung, J. Kim, S. Kim 
G. Venne, S. Pang, Y. Tse, R. Ellis  Osteoarthritis and Cartilage 
High flexion is associated with knee osteoarthritis - of four high flexion postures, flat foot squatting minimizes knee adduction moments  H.C. Chong,
Prospective changes in cartilage thickness correlate with knee kinematics at peak loading during walking following anterior cruciate ligament reconstruction 
Replicability of recommended exercise interventions for knee osteoarthritis: a descriptive systematic review of current clinical guidelines and recommendations 
P. Yuan, X. Zhang, W. Yang, W. Kang, B. Yang, J. li, B. Chen, X. Li, B
Synovial changes detected by ultrasound in people with knee osteoarthritis – A meta- analysis of observational studies  A. Sarmanova, M. Hall, J. Moses,
Association of ultrasound-defined structural changes with regional and diffuse knee pain patterns – Oulu Knee Osteoarthritis study  J. Podlipská, P. Kaukinen,
Pain has a stronger association with thigh muscle strength than the radiographic stage of knee osteoarthritis - data from the Osteoarthritis Initiative 
Effect of newly developed S(+)-flurbiprofen plaster (SFPP) on inflammation and pain–a study on rat adjuvant-induced arthritis model  M. Sugimoto, Y. Toda,
Anti-inflammatory Properties of SM04690, a Small Molecule Inhibitor of the Wnt Pathway as a Potential Treatment for Knee Osteoarthritis  V. Deshmukh,
B. Vafaeian, S. Adeeb, M. El-Rich, J. Jaremko 
Legbrace limits maximum tibeofemoral force during gait
J. Ranstam  Osteoarthritis and Cartilage 
The influence of early osteoarthritic collagen network de-structuring in articular cartilage on the tissue stiffness and swelling properties  M. Nickien,
The centre of mass trajectory is a sensitive and responsive measure of compensations for pain and weakness among individuals with knee osteoarthritis.
N. Bodick, J. Lufkin, C. Willwerth, A. Kumar, J. Bolognese, C
R2−R1ρ as a Potential Biomarker for Tracking Cartilage Matrix Changes in Osteoarthritic Knees after Hyaluronic Acid Injection  M. Tanaka, A. Azus, V.
A new lipid formulation of low dose (1200mg) ibuprofen is non-inferior to high dose (2400mg) standard ibuprofen capsules in managing episodic knee pain.
Y. Levy, A. Hasegawa, S. Patil, M. Lotz, D. D'Lima 
Effect of soft braces on pain and physical function in patients with knee osteoarthritis: systematic review with meta-analyses  T. Cudejko, M. van der.
C. -H. Chou, H. -G. Wisniewski, P. Band, J. Huebner, T. Stabler, C
A randomised controlled trial to investigate walking 6,000 steps per day on pain and function in knee osteoarthritis progression: the walkout study  M.S.
Differential response of placebo treatments in osteoarthritis trials: a systematic review and network meta-analysis  R.R. Bannuru, C.H. Schmid, M.C. Sullivan,
Emerging role of endothelin receptor type B in regulating chondrogenic and hypertrophic changes of human mesenchymal stem cells  M. Au, M. Zhu, W.-J.
Comparing clinical outcomes of exercise intervetions according to the American college of sports medicine guidelines for strength training to other types.
Z. Huang, T. Stabler, F. Pei, V. Kraus  Osteoarthritis and Cartilage 
Lack of a clear disease modifying activity of celecoxib in treatment of end-stage knee osteoarthritis: a rondomized observer blinded clinical trial  E.M.
Acute influences of draw-in maneuver for knee adduction moment and hip and trunk muscle activities during a person's manner of walking  S. Ota, H. Ohko,
Elevated cartilage T2 and increased severity of cartilage defects at baseline are associated with the development of knee pain over 7 years  G.B. Joseph,
A systematic review of the efficacy and general safety of antibodies to NGF in the treatment of OA of the hip or knee  T.J. Schnitzer, J.A. Marks  Osteoarthritis.
Damps provide a link between joint tissue damage and pain through direct activation of TLR4 expressed by sensory neurons  R.E. Miller, P.B. Tran, S. Ishihara,
D.J. Hunter  Osteoarthritis and Cartilage 
Low-dose SoluMatrix meloxicam results in clinically meaningful improvements in pain in a phase 3 study of patients with osteoarthritis  R. Altman, M.
Total knee replacement followed by a non-surgical treatment program reduce localized and spreading pain sensitization – A pre-defined ancillary analysis.
Evidence for bone mineral density and bone resorption in middle and elderly women with knee osteoarthritis in Shanghai: a cross sectional study  Q. Xiaofeng 
Walking with increased foot progression angle can reduce joint compression in individuals with knee OA  K. Manal, T.S. Buchanan  Osteoarthritis and Cartilage 
Effects of exercise and weight loss on interstitial matrix turnover and tissue inflammation biomarkers in adults with knee osteoarthritis: the intensive.
Multivariate pattern analysis of physical activity and cartilage health: data from the osteoarthritis initiative  E. Halilaj, T.J. Hastie, G.E. Gold,
Osteoarthritis and Cartilage
Imaging biomarker with T1 and T2 mappings in osteoarthritis – In vivo human articular cartilage study  C. Yan, C. Wong, T. Li, N. Gong, Q. Chan, K. Chiu 
The effect of quadriceps-strengthening exercise on quadriceps and knee biomichanics during walking in adults with knee osteoarthritis: a randomized controlled.
How does lower leg alignment differ between soccer players, other athletes and non- athletic controls?  W. colyn, R. Agricola, N. Arnout, J. Verhaar, J.
H. Khan, D. Aitken, C. Ding, L. Blizzard, J. -P. Pelletier, J
Knee kinematic and kinetic modifications under body weight unloading during overground walking at a constant speed  A.G. Fischer, E.M. Debbi, A. Wolf 
An intra-articular, extended release formulation of triamcinolone (FX006) affords clinically relevant improvements in pain and function of knee osteoarthritis:
Triamcinolone acetonide extended-release injectable suspension (TA-ER) provides clinically relevant improvements in pain and function of knee osteoarthritis:
A gait analysis using wearable devices on activities of daily life in patients with knee osteoarthritis  Y. Iwama, K. Harato, A. Sakurai, K. Nishizawa,
E. M. Debbi, B. Bernfeld, E. Gray, M. Salai, Y. Levy, A. Gold, R
E. M. Debbi, B. Bernfeld, M. Falah, A. Greental, A. Sigal, R. Debi, A
A. Carlson, B. Bothner, R. June  Osteoarthritis and Cartilage 
General Information Osteoarthritis and Cartilage
Long-term effects of vitamin d supplementation and maintaining vitamin d sufficiency on knee osteoarthritis over 5 years  B. Antony, S. Zheng, J. Burgess,
Presentation transcript:

Ability in tissue penetration and clinical utility of S-flurbiprofen plaster for knee osteoarthritis  H. Matsumoto, I. Yataba, N. Otsuka, Y. Hoshino  Osteoarthritis and Cartilage  Volume 24, Pages S501-S502 (April 2016) DOI: 10.1016/j.joca.2016.01.917 Copyright © 2016 Terms and Conditions

Figure 1. (A) SFP concentrations in the synovial tissue Figure 1. (A) SFP concentrations in the synovial tissue. (B) Absorption ratios. Data are presented as mean + standard deviation. The significance level was set at 5% (two-sided, Welch’s t-test). Osteoarthritis and Cartilage 2016 24, S501-S502DOI: (10.1016/j.joca.2016.01.917) Copyright © 2016 Terms and Conditions

Figure 2. VAS changes in knee pain at standing up from chair Figure 2. VAS changes in knee pain at standing up from chair. Data are presented as least squares mean + upper 95% confidence limit of change from baseline to the end of the trial. The significance level was set at 2.5% (one-sided, ANCOVA). Osteoarthritis and Cartilage 2016 24, S501-S502DOI: (10.1016/j.joca.2016.01.917) Copyright © 2016 Terms and Conditions