Aberrant Crypt Foci: Detection, Gene Abnormalities, and Clinical Usefulness Tetsuji Takayama, Koji Miyanishi, Tsuyoshi Hayashi, Takehiro Kukitsu, Kunihiro.

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Presentation transcript:

Aberrant Crypt Foci: Detection, Gene Abnormalities, and Clinical Usefulness Tetsuji Takayama, Koji Miyanishi, Tsuyoshi Hayashi, Takehiro Kukitsu, Kunihiro Takanashi, Hirotoshi Ishiwatari, Takahiro Kogawa, Tomoyuki Abe, Yoshiro Niitsu Clinical Gastroenterology and Hepatology Volume 3, Issue 7, Pages S42-S45 (July 2005) DOI: 10.1016/S1542-3565(05)00257-0 Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 1 Identification of ACF by magnifying endoscopy. The panel shows ACF identified by magnifying endoscopy (EC-485-ZW; Fujinon-Toshiba ES system). Clinical Gastroenterology and Hepatology 2005 3, S42-S45DOI: (10.1016/S1542-3565(05)00257-0) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 2 Three different types of ACF. Endoscopic appearances of (A) nondysplastic nonhyperplastic ACF, (B) nondysplastic hyperplastic ACF, and (C) dysplastic ACF. Histologic findings of (D) nondysplastic nonhyperplastic ACF, (E) nondysplastic hyperplastic ACF, and (F) dysplastic ACF. Clinical Gastroenterology and Hepatology 2005 3, S42-S45DOI: (10.1016/S1542-3565(05)00257-0) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 3 Colon carcinogenesis through ACF. Accumulating data on ACF strongly suggest that ACF, particularly dysplastic ACF, are precursor lesions of adenoma and subsequent cancer. Clinical Gastroenterology and Hepatology 2005 3, S42-S45DOI: (10.1016/S1542-3565(05)00257-0) Copyright © 2005 American Gastroenterological Association Terms and Conditions