Platelet activating factor acetylhydrolase decreases lung reperfusion injury Jong D Kim, MD, Craig J Baker, MD, Randall F Roberts, MD, Sevak H Darbinian,

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Presentation transcript:

Platelet activating factor acetylhydrolase decreases lung reperfusion injury Jong D Kim, MD, Craig J Baker, MD, Randall F Roberts, MD, Sevak H Darbinian, MD, Keith A Marcus, MS, Suzanne M Quardt, MD, Vaughn A Starnes, MD, Mark L Barr, MD The Annals of Thoracic Surgery Volume 70, Issue 2, Pages 423-428 (August 2000) DOI: 10.1016/S0003-4975(00)01405-3

Fig 1 Oxygen tension (Po2 in mm Hg) after 6 hours of cold ischemic storage for Euro-Collins (EC) and University of Wisconsin (UW) solutions. Oxygenation improved for both EC and UW when platelet activating factor-acetylhydrolase was added to the flush solution and the reperfusate blood (EC: 141 ± 8 versus 113 ± 9 mm Hg, p = 0.04; UW: 328 ± 8 versus 285 ± 12 mm Hg, p = 0.01). The Annals of Thoracic Surgery 2000 70, 423-428DOI: (10.1016/S0003-4975(00)01405-3)

Fig 2 Oxygen tension (Po2 in mm Hg) after 12 hours of cold ischemic storage for Euro-Collins (EC) and University of Wisconsin (UW) solutions. Oxygenation improved for UW when platelet activating factor-acetylhydrolase (PAF-AH) was added to the flush solution and the reperfusate blood (302 ± 9 versus 260 ± 14 mm Hg, p = 0.03). There was also a significant improvement with PAF-AH added to the flush solution only (group II) when compared with control (300 ± 9 versus 260 ± 14 mm Hg, p = 0.04). The Annals of Thoracic Surgery 2000 70, 423-428DOI: (10.1016/S0003-4975(00)01405-3)

Fig 3 Compliance measured after 6 hours of cold ischemic storage for Euro-Collins (EC) and University of Wisconsin (UW) solutions. Compliance increased for EC when platelet activating factor-acetylhydrolase was added to the flush solution and the reperfusate blood (0.164 ± 0.006 versus 0.145 ± 0.003 mL/cm H2O, p = 0.04). For UW, all three groups showed improvements in compliance when compared with control (group II: 0.250 ± 0.009 versus 0.219 ± 0.008 mL/cm H2O, p = 0.03; group III: 0.253 ± 0.011 versus 0.219 ± 0.008 mL/cm H2O, p = 0.01; group IV: 0.245 ± 0.004 versus 0.219 ± 0.008 mL/cm H2O, p = 0.01). The Annals of Thoracic Surgery 2000 70, 423-428DOI: (10.1016/S0003-4975(00)01405-3)

Fig 4 Compliance measured after 12 hours of cold ischemic storage for Euro-Collins (EC) and University of Wisconsin (UW) solutions. For EC, only group IV showed improvement in compliance when compared with control (0.1377 ± .003 versus 0.1258 ± .003 mL/cm H2O, p = 0.031). For UW, groups II and IV both showed improvements in compliance compared with control (group II: 0.244 ± 0.014 versus 0.194 ± 0.008, p = 0.003; group IV: 0.240 ± .008 versus 0.194 ± .008 mL/cm H2O, p = 0.004). The Annals of Thoracic Surgery 2000 70, 423-428DOI: (10.1016/S0003-4975(00)01405-3)

Fig 5 Capillary filtration coefficient (Kf, mL/min/mm Hg/100 g) after 6 hours of cold ischemic storage for Euro-Collins (EC) and University of Wisconsin (UW) solutions. Kf decreased when platelet activating factor-acetylhydrolase was added to EC flush and reperfusate blood (1.58 ± 0.26 versus 2.42 ± 0.27 mL/min/mm Hg/100 g, p = 0.02). The Annals of Thoracic Surgery 2000 70, 423-428DOI: (10.1016/S0003-4975(00)01405-3)

Fig 6 Capillary filtration coefficient (Kf, mL/min/mm Hg/100 g) after 12 hours of cold ischemic storage for Euro-Collins (EC) and University of Wisconsin (UW) solutions. Kf decreased for both EC and UW when platelet activating factor-acetylhydrolase was added to the flush solution and the reperfusate blood (EC: 2.45 ± 0.36 versus 4.16 ± 0.60 mL/min/mm Hg/100 g, p = 0.01; UW: control (0.65 ± 0.10 versus 1.35 ± 0.19 mL/min/mm Hg/100 g, p = 0.02). EC also showed lower Kf at 12 hours of storage for group III compared with control (2.78 ± 0.22 versus 4.16 ± 0.60 mL/min/mm Hg/100 g, p = 0.05). The Annals of Thoracic Surgery 2000 70, 423-428DOI: (10.1016/S0003-4975(00)01405-3)