The “Domino Theory” of Hunger: The Hypothalamus Is Hot

Slides:

Advertisements

Similar presentations

SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration Amit R. Reddi, Valeria C. Culotta Cell Volume 152, Issue 1, Pages (January.

Advertisements

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

The Neurobiology of Decision: Consensus and Controversy Joseph W. Kable, Paul W. Glimcher Neuron Volume 63, Issue 6, Pages (September 2009) DOI:

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Treating the Developing versus Developed Brain: Translating Preclinical Mouse and Human Studies B.J. Casey, Charles E. Glatt, Francis S. Lee Neuron Volume.

Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

Common Sense about Taste: From Mammals to Insects David A. Yarmolinsky, Charles S. Zuker, Nicholas J.P. Ryba Cell Volume 139, Issue 2, Pages (October.

The Pathobiology of Vascular Dementia Costantino Iadecola Neuron Volume 80, Issue 4, Pages (November 2013) DOI: /j.neuron Copyright.

Decision Making as a Window on Cognition Michael N. Shadlen, Roozbeh Kiani Neuron Volume 80, Issue 3, Pages (October 2013) DOI: /j.neuron

Contour Saliency in Primary Visual Cortex Wu Li, Valentin Piëch, Charles D. Gilbert Neuron Volume 50, Issue 6, Pages (June 2006) DOI: /j.neuron

Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis Wing-Hang Tong, Tracey A. Rouault Cell.

PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors Joan Sanchez-Gurmaches, Chien-Min.

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.

A View to a Kill: The Bacterial Type VI Secretion System Brian T. Ho, Tao G. Dong, John J. Mekalanos Cell Host & Microbe Volume 15, Issue 1, Pages 9-21.

Lipin-1 Regulates Autophagy Clearance and Intersects with Statin Drug Effects in Skeletal Muscle Peixiang Zhang, M. Anthony Verity, Karen Reue Cell Metabolism.

Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages (June 2013) DOI:

Mechanisms of Age-Related Macular Degeneration Jayakrishna Ambati, Benjamin J. Fowler Neuron Volume 75, Issue 1, Pages (July 2012) DOI: /j.neuron

Adaptation to Natural Binocular Disparities in Primate V1 Explained by a Generalized Energy Model Ralf M. Haefner, Bruce G. Cumming Neuron Volume 57, Issue.

Gastrulation Movements: the Logic and the Nuts and Bolts Maria Leptin Developmental Cell Volume 8, Issue 3, Pages (March 2005) DOI: /j.devcel

Oxygen Sensors at the Crossroad of Metabolism Julián Aragonés, Peter Fraisl, Myriam Baes, Peter Carmeliet Cell Metabolism Volume 9, Issue 1, Pages

Ghrelin—a new player in glucose homeostasis?

Jochen G. Schneider, Joseph H. Nadeau Cell Metabolism

Interleukins and Atherosclerosis: A Dysfunctional Family Grows

Energy Sparing Orexigenic Inflammation of Obesity

FSH versus estrogen: Who's guilty of breaking bones?

Does Hypothalamic Inflammation Cause Obesity?

More Than Satiety: Central Serotonin Signaling and Glucose Homeostasis

Volume 13, Issue 1, Pages 5-6 (January 2011)

Serotonin and the Orchestration of Energy Balance

Looking for food in all the right places?

Volume 12, Issue 5, Pages (November 2010)

Volume 24, Issue 3, Pages (September 2016)

Motivation to Eat—AgRP Neurons and Homeostatic Need

A Sympathetic View on Fat by Leptin

Volume 15, Issue 1, Pages (January 2012)

Burning Fat and Building Bone by FSH Blockade

Come on BAIBA Light My Fire

Burning Fat and Building Bone by FSH Blockade

Is Predisposition to NAFLD and Obesity Communicable?

Filling the Interstices

FSH versus estrogen: Who's guilty of breaking bones?

Volume 13, Issue 1, Pages 5-6 (January 2011)

Jelena Kolic, James D. Johnson Cell Metabolism

Volume 26, Issue 1, Pages 6-7 (July 2017)

The CAMplexities of Central Ghrelin

Why We Should Put Clothes on Mice

Metabolic and Non-Cognitive Manifestations of Alzheimer’s Disease: The Hypothalamus as Both Culprit and Target of Pathology Makoto Ishii, Costantino.

Making Biological Sense of GWAS Data: Lessons from the FTO Locus

IL-6 Muscles In on the Gut and Pancreas to Enhance Insulin Secretion

Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes

Synaptic Plasticity of Feeding Circuits: Hormones and Hysteresis

Volume 152, Issue 1, (January 2013)

Modifying Mitochondrial tRNAs: Delivering What the Cell Needs

Lasker Lauds Leptin Cell Metabolism

Human Visceral-Fat-Specific Glucocorticoid Tuning of Adipogenesis

Food for Thought: Revisiting the Complexity of Food Intake

A New Role for Glia in Leptin Action and Energy Balance

Leptin's RIGHT Turn to the Brain Stem

Treating obesity: Does antagonism of NPY fit the bill?

Oxytocin: The Neuropeptide of Love Reveals Some of Its Secrets

Hap1 and GABA: Thinking about food intake

Macrophage Metabolism Shapes Angiogenesis in Tumors

Lysosomal Rag-ulation of mTOR Complex 1 Activity

David Hubel and Torsten Wiesel

Estrogens and Obesity: Is It All in Our Heads?

Lipotoxicity, β Cell Dysfunction, and Gestational Diabetes

Volume 148, Issue 1, (January 2012)

Presentation transcript:

The “Domino Theory” of Hunger: The Hypothalamus Is Hot Charles V. Mobbs Cell Metabolism Volume 5, Issue 1, Pages 1-2 (January 2007) DOI: 10.1016/j.cmet.2006.12.005 Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 1 The “Domino Theory” of Hunger Food deprivation reduces the production of leptin by fat. This removes the inhibitory effect of leptin on corticosterone secretion by the adrenal gland (through a mechanism still unresolved), leading to increased corticosterone secretion. The increased corticosterone stimulates the production of type 2 deiodinase in hypothalamic tanycytes, leading to increased local production of T3. T3 diffuses to nearby NPY/AgRP neurons (adjacent, but shown spatially separate here for clarity), where it stimulates UCP2 production. Abrogation of any of these steps attenuates several neuroendocrine responses to fasting. Cell Metabolism 2007 5, 1-2DOI: (10.1016/j.cmet.2006.12.005) Copyright © 2007 Elsevier Inc. Terms and Conditions