Summary of this study. Summary of this study. Cysteinyl-leukotrienes (cys-LTs) stimulate mitogenesis of bronchial fibroblasts only in the presence of RTK.

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Summary of this study. Summary of this study. Cysteinyl-leukotrienes (cys-LTs) stimulate mitogenesis of bronchial fibroblasts only in the presence of RTK growth factors, not through transactivation of epidermal growth factor receptor (EGFR) by a disintegrin and metalloproteinase (ADAM)-mediated ligand shedding (indicated by arrows covered by a cross), but through intracellular, protein kinase C (PKC)-mediated augmentation of growth factor-dependent phosphorylation of signalling molecules. FGF(R): fibroblast growth factor (receptor); LT: leukotriene; PDGF(R): platelet-derived growth factor (receptor); MEK: mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) kinase; MKK: mitogen-activated protein kinase kinase; PI3K: phosphoinositide-3 kinase; Akt: protein kinose B (PKB). Hajime Yoshisue et al. Eur Respir Rev 2006;15:172-174 ©2006 by European Respiratory Society