Trajectory of cartilage loss within 4 years of knee replacement – a nested case–control study from the Osteoarthritis Initiative F. Eckstein, R.M. Boudreau,

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Trajectory of cartilage loss within 4 years of knee replacement – a nested case–control study from the Osteoarthritis Initiative F. Eckstein, R.M. Boudreau, Z. Wang, M.J. Hannon, W. Wirth, S. Cotofana, A. Guermazi, F. Roemer, M. Nevitt, M.R. John, C. Ladel, L. Sharma, D.J. Hunter, C.K. Kwoh Osteoarthritis and Cartilage Volume 22, Issue 10, Pages 1542-1549 (October 2014) DOI: 10.1016/j.joca.2014.04.016 Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Graph showing the study design and methods: OAI participants with KR occurrence between 24 and 60 month (M) follow-up had quantitative cartilage analysis at 2–5 prior time points, providing a minimum of one to a maximum of four 1-year observation periods. Osteoarthritis and Cartilage 2014 22, 1542-1549DOI: (10.1016/j.joca.2014.04.016) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 View of the weight-bearing femoral and their subregions from inferior (top), of the femoro-tibial plates from anterior (middle), and of the tibiae and their subregions from superior: the central subregion of the medial tibia (cMT) was selected as the primary, and the total medial femoro-tibial compartment (MFTC) as the secondary outcome. MT = medial tibia, LT = lateral tibia, cMF = weight-bearing (central) medial femur, cLF = weight-bearing (central) lateral femur, LFTC = lateral femoro-tibial compartment. Osteoarthritis and Cartilage 2014 22, 1542-1549DOI: (10.1016/j.joca.2014.04.016) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Observed rates of cartilage loss (mean and upper 95% CI) in the central subregion of the medial tibia (cMT; see Fig. 2) over 4 years prior to the occurrence of KRs and in matched, non-replaced controls [same sex, age (±5 years) and baseline KLGs (values are without adjustment for pain frequency and BMI)]. The error bars show the lower limits of the 95% CIs. (A) Total KR sample. (B) Subsample of femoro-tibial KRs without medial/lateral JSN mismatch. Osteoarthritis and Cartilage 2014 22, 1542-1549DOI: (10.1016/j.joca.2014.04.016) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions